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Penn State running back Saquon Barkley could not be stopped during the Nittany Lions' Week 4 win at Iowa. And while it was quarterback Trace McSorley who threw the impressive walk-off touchdown, it was Barkley who dazzled with 358 all-purpose yards and a touchdown (not to mention a highlight reel for days). 

As a result of the 21-19 win, Barkley, who leads the Big Ten in receiving yards and is two yards off the lead in rushing, has shot up the latest Heisman odds. As of Sept. 18, he was +800. Here's the latest top 10 via Sports Insights ... 

PlayerOdds

Saquon Barkley, RB, Penn State

+250

Baker Mayfield, QB, Oklahoma

+275

Mason Rudolph, QB, Oklahoma State

+600

Lamar Jackson, QB, Louisville

+700

Sam Darnold, QB, USC

+1000

JT Barrett, QB, Ohio State

+1400

Josh Rose, QB, UCLA

+2000

Royce Freeman, RB, Oregon

+2000

Trace McSorley, QB, Penn State

+2000

Jalen Hurts, QB, Alabama

+2500

Oklahoma quarterback Baker Mayfield rounds out what is currently a two-player race at +275 odds. Then there's a significant drop to No. 3 Mason Rudolph, whose odds have actually remained steady despite a Week 4 loss to TCU. Reigning Heisman winner Lamar Jackson has the fourth-best odds and USC quarterback Sam Darnold rounds out the top five, but his odds have gone down tremendously over the past week (he was +500 as of Sept. 18).