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The SMU Mustangs will take on the Louisiana Tech Bulldogs at 3:30 p.m. ET on Saturday at Joe Aillet Stadium and the game will be broadcast live on CBS Sports Network. SMU is 2-0 on the season but this will be the first time they've had to leave the state of Texas. Meanwhile, Louisiana Tech is 1-1 after giving Mississippi State a 34-35 scare and then beating Southeast Louisiana 45-42.

This will be the sixth all-time meeting between the two programs with Louisiana Tech holding the 4-1 all-time advantage. The Mustangs are favored by 12.5-points in the latest SMU vs. Louisiana Tech odds from Caesars Sportsbook, and the over-under is set at 66. Before entering any Louisiana Tech vs. SMU picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisiana Tech vs. SMU. You can head to SportsLine to see its picks. Here are several college football odds for SMU vs. Louisiana Tech:

  • Louisiana Tech vs. SMU spread: SMU -12.5
  • Louisiana Tech vs. SMU over-under: 66 points
Featured Game | Louisiana Tech Bulldogs vs. SMU Mustangs

What you need to know about Louisiana Tech

Things were close when Louisiana Tech and the Southeastern Louisiana Lions clashed last Saturday, but Louisiana Tech ultimately edged out the opposition 45-42. The Bulldogs were out-gained 594-450 in the game but was able to take advantage of three SELA turnovers and 100 yards in penalties to hold off the FCS opponent.

Louisiana Tech had solid balance in the game with 250 yards and two touchdowns through the air and 200 rushing yards and three scores on the ground. Safety Bee Jay Williamson had a big night with six tackles, two forced fumbles and two interceptions, one of which he returned for a touchdown. Williamson is a disruptive force that Sonny Dykes' squad will have to be aware of at all times.

What you need to know about SMU

Meanwhile, SMU's game against the North Texas Mean Green last Saturday was close at halftime, but SMU turned on the heat in the second half with 28 points. The Mustangs made easy work of North Texas and carried off a 35-12 win. Quarterback Tanner Mordecai threw for 311 yards and four touchdowns in the victory.

Mordecai has now thrown for 628 yards and 11 touchdowns with just two interceptions through two games. Ulysses Bentley IV also had 141 yards rushing and a score in the game. Bentley produced 1,087 scrimmage yards and 12 touchdowns as a redshirt freshman last season and he helps keep defense's honest against SMU's high-powered passing attack.

How to make Louisiana Tech vs. SMU picks

The model has simulated SMU vs. Louisiana Tech 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins SMU vs. Louisiana Tech? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.