South Carolina head coach Shane Beamer's debut went flawlessly well last weekend, as his team blew out Eastern Illinois in a 46-0 final. The Gamecocks will have a much tougher challenge on their hands when they travel to East Carolina on Saturday afternoon. The Pirates are coming off a 33-19 loss at Appalachian State, but they opened as four-point favorites in this game before the line moved the other way.

Kickoff is set for noon ET. The Gamecocks are now 2.5-point favorites in the latest South Carolina vs. East Carolina odds from Caesars Sportsbook, while the over-under is set at 56.5. Before finalizing any East Carolina vs. South Carolina picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. ECU. You can head to SportsLine to see its picks. Here are several college football odds for ECU vs. South Carolina:

  • East Carolina vs. South Carolina spread: South Carolina -2.5
  • East Carolina vs. South Carolina over-under: 56.5 points
Featured Game | East Carolina Pirates vs. South Carolina Gamecocks

What you need to know about East Carolina

Going on the road for a Thursday night game to open the season is never an easy task. East Carolina is better than what it showed at Appalachian State, which is why oddsmakers listed the Pirates as favorites when this line was released. Quarterback Holton Ahlers is the third-leading returning passer in the conference at 240.1 yards per game.

South Carolina is coming off a win over one of the worst teams in the FCS. The Pirates have a capable run defense and can force the Gamecocks to throw the ball. The crowd will be eager to get behind East Carolina in a game where a win would mean a lot to the program.

What you need to know about South Carolina

Meanwhile, South Carolina blanked the Eastern Illinois Panthers last Saturday and took the game 46-0. With the Gamecocks ahead 29-0 at the half, the contest was all but over already at that point. Running back ZaQuandre White was on fire, rushing for one TD and 128 yards on 12 carries in addition to snatching one receiving TD. One of the most memorable plays of the matchup was White's 63-yard touchdown rush in the fourth quarter. 

All eyes will be on the status of a couple South Carolina stars on offense. Quarterback Luke Doty missed the opener as he recovers from an injured foot, but has a chance to return for this matchup. Running back Kevin Harris, who missed the win over Eastern Illinois due to a back injury, is expected to return on Saturday.

How to make East Carolina vs. South Carolina picks

The model has simulated East Carolina vs. South Carolina 10,000 times and the results are in. The model is leaning under on the total, and it also says one side of the spread has all the value. You can only see the pick at SportsLine.

Who wins East Carolina vs. South Carolina? And which side of the spread has all the value? Visit SportsLine right now to see which side of the South Carolina vs. ECU spread you need to jump on, all from the computer model that has crushed its college football picks