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The Ole Miss Rebels and the South Carolina Gamecocks are set to square off in a SEC showdown at 7:30 p.m. ET on Saturday at Vaught-Hemingway Stadium at Hollingsworth Field. South Carolina is 2-4 overall and 1-2 on the road, while Ole Miss is 2-4 overall and 0-3 at home. The Rebels enter Saturday's matchup averaging 38.0 points per game. South Carolina, meanwhile, is giving up an average of 33 points per game this season. 

The Rebels are favored by 11.5-points in the latest Ole Miss vs. South Carolina odds from William Hill Sportsbook, and the over-under is set at 70.5. Before entering any South Carolina vs. Ole Miss picks, you'll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It is a sizzling 37-20 on all top-rated picks through 10 weeks of the 2020 college football season, returning over $900 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ole Miss vs. South Carolina. You can head to SportsLine to see its picks. Here are several college football odds for Ole Miss vs. South Carolina:

  • Ole Miss vs. South Carolina spread: Ole Miss -11.5
  • Ole Miss vs. South Carolina over-under: 70.5 points
  • Ole Miss vs. South Carolina money line: Ole Miss -430, South Carolina +330

What you need to know about Ole Miss

Ole Miss ran circles around the Vanderbilt Commodores in its last outing, and the extra yardage (645 yards vs. 421 yards) paid off. Ole Miss blew past Vanderbilt 54-21. The contest was all but wrapped up at the end of the third, by which point Ole Miss had established a 54-14 advantage. QB Matt Corral had a dynamite game for the Rebels; he passed for six TDs and 412 yards on 34 attempts. For the season, Corral has thrown for 1,846 yards, 18 touchdowns and nine interceptions. 

Wide receiver Elijah Moore also had a big day against the Commodores, hauling in 14 receptions for 238 yards and three touchdowns. Moore ranks third in the nation with 829 receiving yards this season.  

What you need to know about South Carolina

Meanwhile, a victory for the Gamecocks just wasn't in the stars last Saturday as the team never even grasped a temporary lead. The Gamecocks took a serious blow against the Texas A&M Aggies, falling 48-3. South Carolina was down 34-0 at the end of the third quarter, which was just too much to recover from. One thing working against South Carolina was the run-of-the-mill game of its most targeted running back, RB Kevin Harris, who rushed for 39 yards on 13 carries.

Despite their most recent setback, the Gamecocks will be confident they can pull off the upset on Saturday. That's because South Carolina has won each of its last three meetings against the Rebels. In addition, Ole Miss is 0-5 in its last five games at home. 

How to make Ole Miss vs. South Carolina picks

The model has simulated Ole Miss vs. South Carolina 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins South Carolina vs. Ole Miss? And which side of the spread hits over 50 percent of the time? Visit SportsLine now to see which side of the Ole Miss vs. South Carolina spread to back, all from the advanced model that is up over $3,900 on its top-rated college football spread picks, and find out.