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The TCU Horned Frogs will go on the road to open the season when they face the Stanford Cardinal on Friday night. TCU is coming off a 5-7 campaign, failing to qualify for the postseason after making a national championship game appearance the year prior. Stanford has gone 3-9 in each of its last three campaigns in the Pac-12, but it begins a new era in the ACC. The Cardinal are also eyeing their first home victory since 2022 after losing all seven of their home games last year. 

Kickoff is scheduled for 10:30 p.m. ET at Stanford Stadium in Stanford, Calif. After opening at -11, the Horned Frogs are favored by 8.5 points in the latest Stanford vs. TCU odds, while the over/under is down a point to 59.5, per SportsLine consensus. Before entering any TCU vs. Stanford picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.

The model has set its sights on TCU vs. Stanford. You can head to SportsLine to see its picks. Here are several college football betting lines for Stanford vs. TCU:

  • Stanford vs. TCU spread: TCU -8.5
  • Stanford vs. TCU over/under: 59.5 points
  • Stanford vs. TCU money line: TCU -324, Stanford +254
  • Stanford vs. TCU picks: See picks at SportsLine

Why Stanford can cover

Stanford is looking for an improvement under second-year head coach Troy Taylor after posting five straight seasons with four or fewer wins. Three quarterbacks have been competing for the starting job this fall, and all three of them could see time in this game. Ashton Daniels threw for 2,247 yards and 11 touchdowns as a first-year starter last year, so he could have an edge in the battle. 

Daniels also rushed for 292 yards, which were the second-most by a Pac-12 quarterback behind teammate Justin Lamson. Freshman Elijah Brown is also vying for playing time, giving Taylor plenty of options on Friday. TCU went 1-4 on the road last season, which was its third losing season in the last five years. See which team to pick here. 

Why TCU can cover

TCU dropped below .500 last year after making the national championship during the 2022 season, but there were still some positive takeaways. The Horned Frogs averaged 312.2 passing yards per game, which were the second-most in the Big 12. Quarterback Josh Hoover started the final six games of the season, completing 62.1% of his passes for 2,206 yards and 15 touchdowns. 

Hoover is the projected starter entering the season, giving the Horned Frogs a proven option to lead their offense. He is facing a Stanford program that has gone 7-21 at home against Power Five teams over the last five years. The Cardinal have question marks at several positions entering the season, with quarterback being the most notable of them. See which team to pick here. 

How to make Stanford vs. TCU picks

The model has simulated TCU vs. Stanford 10,000 times and the results are in. The model is leaning Under the total, projecting 58 combined points. It also says one side of the spread hits in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Stanford vs. TCU, and which side of the spread hits almost 60% of the time? Visit SportsLine now to see which side of the TCU vs. Stanford spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.