The Syracuse Orange and the No. 19 Wake Forest Demon Deacons are set to square off in an ACC matchup at 3:30 p.m. ET on Saturday at the Carrier Dome. The Orange are 3-2 overall and 2-1 at home, while Wake Forest is 5-0 overall and 1-0 on the road. Syracuse fell 33-30 to the Florida State Seminoles last Saturday. Wake Forest edged the Louisville Cardinals, 37-34.

Wake Forest is averaging 186 rushing yards per game and has scored 11 TDs on the ground. The Demon Deacons are favored by six points in the latest Syracuse vs. Wake Forest odds from Caesars Sportsbook, and the over-under is set at 58.5. Before entering any Wake Forest vs. Syracuse picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Syracuse vs. Wake Forest. You can head to SportsLine to see its picks. Here are several college football odds for Wake Forest vs. Syracuse:

  • Syracuse vs. Wake Forest spread: Wake Forest -6
  • Syracuse vs. Wake Forest over-under: 58.5 points

What you need to know about Syracuse

Syracuse lost to FSU on a 34-yard field goal as time expired in its last game. Garrett Shrader passed for one TD and 150 yards on 23 attempts in addition to rushing for three TDs and  a career-high 137 yards. Shrader rushed for a 55-yard TD in the second quarter. Sean Tucker rushed for 102 yards on 24 attempts. 

Syracuse failed to convert on 10 of 12 third-down attempts and on all of its three fourth down conversion attempts in the loss. Tucker leads the ACC with 127.6 rushing yards per game. The Orange are first in the ACC with 20 sacks. 

What you need to know about Wake Forest

Nick Sciba hit a 29-yard field goal with 22 seconds remaining to lift Wake Forest over Louisville. Justice Ellison rushed for 41 yards on seven attempts on the game-winning drive. Sam Hartman passed for two TDs and 324 yards on 39 attempts in addition to rushing for one TD and 35 yards. Taylor Morin caught six passes for 122 yards and a TD. 

Jaquarii Roberson had six receptions for 135 yards vs. Louisville. Wake Forest has won its first four games in four of the past six seasons. Sciba has made 22 consecutive field-goal attempts, the longest streak in the country. 

How to make Wake Forest vs. Syracuse picks

The model is leaning under on the total, and it's also generated a point-spread pick that is hitting in almost 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Syracuse vs. Wake Forest? And which side of the spread hits almost 60 percent of the time? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.