The TCU Horned Frogs and the Houston Cougars will face off in a Big 12 clash on Saturday. This will be Houston's first Big 12 game after joining the conference this year, following 10 years in the AAC. Both teams are 1-1, with Houston coming off an 8-5 record last year, while TCU went 13-2 and was runner-up in the CFP Championship Game.

Kickoff is at 8 p.m. ET from TDECU Stadium in Houston. The Horned Frogs are 7.5 points in the latest Houston vs. TCU odds, and the over/under is 64 points. Before entering any TCU vs. Houston picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Houston vs. TCU. You can head to SportsLine to see its picks. Here are several college football odds for TCU vs. Houston:

  • Houston vs. TCU spread: Houston +7.5
  • Houston vs. TCU over/under: 64 points
  • Houston vs. TCU money line: Houston: +235, TCU: -294
  • Houston vs. TCU picks: See picks at SportsLine

What you need to know about TCU

Last Saturday, everything came up roses for TCU at home against Nicholls State as the squad secured a 41-6 victory. Quarterback Chandler Morris was on fire as he threw for 263 yards and two touchdowns, in addition to rushing for 63 yards and a touchdown. Wide receiver Jaylon Robinson also helped out by posting a receiving touchdown.

The Horned Frogs have one of the most productive running backs in the nation in Emani Bailey. The Louisiana transfer is averaging 7.0 yards per carry and ranks second in the Big 12 with 231 rushing yards. TCU also has a devastating pass rush and has accumulated seven sacks through two games.

What you need to know about Houston

Meanwhile, Houston fought the good fight in its overtime contest against Rice on Saturday but wound up with a less-than-desirable result. Houston fell just short by a score of 43-41. The losing side was boosted by QB Donovan Smith, who threw for 260 yards and two touchdowns, in addition to 57 yards on the ground and three rushing scores. Receiver Matthew Golden was another key contributor, finding the endzone twice on 60 receiving yards.

Smith now has four passing and three rushing scores on the year, accounting for seven of Houston's eight touchdowns. His top target in the passing game is Sam Brown, who is making quite the Big 12 debut. He leads the conference in both receptions (15) and receiving yards (244) but is still looking for his first touchdown. See which team to pick here.

How to make Houston vs. TCU picks

The model has simulated TCU vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits over 60% of the time. You can only see the pick at SportsLine.

So who wins Houston vs. TCU, and which side of the spread hits in over 60% of simulations? Visit SportsLine now to see which side of the TCU vs. Houston spread to jump on, all from the advanced computer model that's up more than $2,500 on its top-rated college football spread picks since its inception, and find out.