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Tennessee will be looking to level the all-time series with Missouri as the teams meet for the 10th time in history on Saturday afternoon. The Tigers currently hold a 5-4 advantage in the series, but they were blown out in a 35-12 final last season. Both teams are coming off disappointing losses in Week 4, as Tennessee fell to Florida, while Missouri lost to Boston College.

Kickoff is set for noon ET. The Tigers are 2.5-point favorites in the latest Missouri vs. Tennessee odds at Caesars Sportsbook, while the over-under for points scored is 65.5. Before entering any Tennessee vs. Missouri picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on an 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Missouri vs. Tennessee. You can head to SportsLine to see its picks. Here are several college football odds for Tennessee vs. Missouri:

  • Missouri vs. Tennessee spread: Missouri -2.5
  • Missouri vs. Tennessee over-under: 65.5 points

What you need to know about Missouri

Tennessee's offense has struggled with penalties and costly turnovers this season -- those mistakes doomed the Vols in the second half of their loss at Florida. They are also dealing with some uncertainty at quarterback, as Hendon Hooker is questionable to start this game. Missouri has struggled defensively, but its offense has been putting up points.

The Tigers have only allowed three sacks, giving sophomore quarterback Connor Bazelak plenty of time to find his weapons through the air. He has completed 68.8 percent of his passes for 1,200 yards and 10 touchdowns. Running back Tyler Badie leads the SEC in yards from scrimmage (593) and is tied for the lead in touchdowns (8).

What you need to know about Tennessee

Meanwhile, Tennessee's matchup against the Florida Gators last Saturday was up for grabs at halftime, but Tennessee was blanked 21-0 in the second half. The Vols appeared to be heading toward a cover (+19) in that matchup, but a late Florida touchdown gave the Gators a 38-14 win and a cover. Tennessee moves extremely fast on offense and it has two running backs putting up solid numbers. Tiyon Evans, who scored on a screen pass against Florida, has 211 yards on the ground, while Jabari Small has 194 yards on the ground.

Hooker appeared to be locking down the quarterback job, but he left the Florida game early with an undisclosed injury. If he's unable to go, Joe Milton III, who started the first two games of the season before sustaining a leg injury, would likely get the call. 

How to make Missouri vs. Tennessee picks

The model has simulated Missouri vs. Tennessee 10,000 times and the results are in. It is leaning under on the total, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You can only see the pick at SportsLine.

So who wins Missouri vs. Tennessee? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks