Pac-12 Conference contenders from a year ago kick off their regular seasons when the Arizona State Sun Devils face the No. 20 USC Trojans on Saturday. The Sun Devils tied for third place in the Pac-12 South at 4-5 and 8-5 overall in 2019, while the Trojans took second in the South at 7-2 and 8-5 overall. Arizona State finished last season on a three-game winning streak and was 2-3 on the road. USC won five of six on its home field a year ago.

The game from the Los Angeles Coliseum is slated to start at noon ET. Arizona State's defense allowed 23.1 points per game in 2019, while USC allowed 27.8. The Trojans are favored by 11 points in the latest USC vs. Arizona State odds from William Hill Sportsbook, while the over-under for total points scored is 55.5. Before making any Arizona State vs. USC picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 31-19 on top-rated picks through nine weeks of the 2020 college football season, returning over $600 in profit already. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Southern Cal vs. Arizona State. You can visit SportsLine now to see the picks. Here are the college football odds from William Hill and trends for Arizona State vs. Southern Cal:

  • Arizona State vs. USC spread: USC -11
  • Arizona State vs. USC over-under: 55.5 points
  • Arizona State vs. USC money line: Arizona State +330, USC -410
  • ASU: Cristian Zendejas opens the season with the nation's second-longest active streak of field goals made with 11
  • USC: Returning wide receivers accounted for 194 receptions and 18 touchdowns last season

Why USC can cover

The defensive front should be a position of strength once again for the Trojans. Plugging the middle will be junior defensive lineman Marlon Tuipulotu, who registered 46 tackles, including 23 solo and six tackles for loss, in 12 starts. He also had two sacks for 10 yards, one forced fumble and three pass breakups. His best game in 2019 was a six-tackle performance against Notre Dame.

Also bolstering the defense is junior linebacker Kana'i Mauga, who was fourth in tackles with 61, including 30 solo, and seven for loss a year ago. He also had three sacks for 20 yards, two pass breakups, one forced fumble and one interception for 11 yards. For his career, he has 75 tackles, including eight for loss and three sacks for 20 yards. Mauga has appeared in 25 games with eight starts.

Why Arizona State can cover

Sun Devils sophomore quarterback Jayden Daniels opens the season with the nation's third-longest active streak of consecutive passes thrown without an interception at 157. Last season, Daniels completed 205 of 338 passes (60.7 percent) for 2,943 yards and 17 touchdowns and two interceptions with a rating of 149.2. Among quarterbacks with at least 200 attempts, he was tied for the fewest interceptions nationally.

Daniels' top returning target is senior wide receiver Frank Darby. Darby caught 31 passes for 616 yards, second-most yards on the team. He also tied with a team-high eight touchdown receptions. Darby's 19.87 yards per reception last season was 10th in the country and second among Pac-12 receivers.

How to make USC vs. Arizona State picks

SportsLine's model is leaning under on the total. In fact, it says Arizona State running backs will combine for just over 110 yards and one touchdown, while USC backs will be held to under 120 yards rushing and one TD. It has also generated an against-the-spread pick that cashes in almost 60 percent of simulations. You can only get the pick at SportsLine

So who wins Arizona State vs. USC? And which side of the spread cashes in almost 60 percent of simulations? Visit SportsLine now to see which side of the USC vs. Arizona State spread to jump on, all from the advanced model that is up over $4,100 on its top-rated college football picks over the past four-plus seasons, and find out.