The No. 6 USC Trojans look to snap a losing streak to the No. 15 Notre Dame Fighting Irish on Saturday. Notre Dame has won the last four matchups in the rivalry, including a 31-16 win in South Bend in 2021. The 2022 edition will take place at Los Angeles Memorial Coliseum as the regular season finale for both teams. Notre Dame is 8-3 this season, including four wins in a row, and USC is 10-1 overall and 6-0 at home as the Trojans remain in the College Football Playoff hunt.

Caesars Sportsbook lists the Trojans as 4-point home favorites for this 7:30 p.m. ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 63.5 in the latest Notre Dame vs. USC odds. Before making any USC vs. Notre Dame picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. Notre Dame and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model's picks. Now, here are several college football odds and trends for Notre Dame vs. USC:

  • Notre Dame vs. USC spread: USC -4
  • Notre Dame vs. USC over/under: 63.5 points
  • Notre Dame vs. USC money line: USC -195, ND +162
  • ND: The Irish are 6-5 against the spread this season
  • USC: The Trojans are 7-4 against the spread this season
  • Notre Dame vs. USC picks: See picks at SportsLine
Featured Game | USC Trojans vs. Notre Dame Fighting Irish

Why Notre Dame can cover

Notre Dame is playing incredibly well in recent days, winning eight of the last nine games. The Fighting Irish have won 19 straight games in November, the longest active streak in FBS, and Notre Dame blasted Boston College by a 44-0 margin last week. On offense, Notre Dame is averaging 39.8 points per game in the last five games and the Irish are putting up 34.4 points per game with Drew Pyne at quarterback.

Notre Dame is also converting 44.7% of third down attempts, and Marcus Freeman's team is averaging 191.2 rushing yards per game with two players producing at least 695 rushing yards. Notre Dame is also electric on defense, giving up only 317.2 total yards and 20.3 points per game. The Fighting Irish are above-average in rushing defense and passing defense, with Notre Dame putting consistent pressure on opponents with 33 sacks in 11 games.

Why USC can cover

USC is led by one of the nation's best players in quarterback Caleb Williams. Williams is a prominent contender for the 2022 Heisman Trophy, and he is averaging 316.4 passing yards per game with 33 touchdowns and three interceptions. Williams ranks in the top six of FBS in both yards and touchdown passes, and he ranks in the top 10 of the country in passing efficiency (167.6). Williams threw for 470 yards in last week's win over UCLA, and he has an elite wide receiver on the outside in Jordan Addison

Addison won the Fred Biletnikoff award as the nation's best receiver in 2021 with Pittsburgh, and he led the country with 17 touchdown catches. Addison has four 100-yards games since arriving at USC, including 11 catches for 178 yards against UCLA last week. Overall, USC is No. 3 in the country in scoring, averaging 42.9 points per game, and the Trojans are in the top four of the nation in total yards and passing yards. USC has scored 40 points or more in five straight games, and the Trojans are No. 2 in the nation with a 54.3% third down efficiency rate. USC is also strong on the ground, averaging 182.2 rushing yards per game, and the Trojans are averaging 5.3 yards per rush attempt.

How to make USC vs. Notre Dame picks

SportsLine's model is leaning Under on the total, projecting the teams to combine for 61 points. The model also says one side of the spread hits well over 50% of the time. You can only get the model's pick at SportsLine

So who wins Notre Dame vs. USC? And which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.