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A Pac-12 battle is on tap between the Oregon State Beavers and the USC Trojans at 10:30 p.m. ET next Saturday at United Airlines Field at the Los Angeles Memorial Coliseum. USC (2-1) is coming off a 45-14 bounce back, blowout win over Washington State, while Oregon State (2-1) is riding a two-game winning streak after beating Hawaii and Idaho in their last two games.

USC is favored by 13 points in the latest USC vs. Oregon State odds from Caesars Sportsbook, and the over-under is set at 63. Before locking in any Oregon State vs. USC picks, you need to check out the college football predictions and analysis from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on USC vs. Oregon State and just revealed its CFB picks and predictions. You can head to SportsLine to see the model's college football picks. Here are several college football odds for USC vs. Oregon State:

  • USC vs. Oregon State spread: USC -13
  • USC vs. Oregon State over-under: 63 points
  • USC vs. Oregon State moneyline: USC -440, Oregon State +340
Featured Game | USC Trojans vs. Oregon State Beavers

What you need to know about USC

The Trojans were embarrassed at home by Stanford two weeks ago, resulting in Clay Helton losing his job as the team's head coach. USC took out their frustrations on Washington State Cougars last week with a dominant 45-14 win on the road. Wide receiver Drake London was the offensive standout of the matchup for USC, catching 13 passes for 170 yards and two touchdowns.

Expect the Trojans to once again be highly motivated in their second game under interim head coach Donte Williams. Starting quarterback Kedon Slovis (neck) is set to return to action. 

What you need to know about Oregon State

History is not on Oregon State's side in this matchup. In games against USC in Los Angeles, the Beavers own an all-time overall record of 3-42-3. Still, OSU is a team that is feeling confident after notching impressive wins in back-to-back weeks after dropping its opener to Purdue.

Oregon State will likely lean on standout running back B.J. Baylor and attempt to control the ball against USC in this critical Pac-12 matchup.

How to make Oregon State vs. USC picks

The model has simulated USC vs. Oregon State 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the model's USC vs. Oregon State pick at SportsLine.

So who wins Oregon St. vs. USC? And which side of the spread cashes in well over 50 percent of simulations?  Visit SportsLine now to see which side of the Oregon State vs. USC spread to jump on, all from the advanced model that finished the past five-plus years up nearly $3,000 on its FBS college football picks, and find out.