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The Washington State Cougars and the USC Trojans will face off in a Pac-12 clash at 3:30 p.m. ET on Saturday at Clarence D. Martin Stadium. The Trojans fired head coach Clay Helton in his seventh season at the helm earlier this week and cornerbacks coach Donte Williams will serve as the interim coach. Helton was 46-24 as head coach and was 3-2 against Washington State as USC's head coach.

However, Washington State covered in three of those five head-to-head matchups and with Helton's imprint still visible, Nick Rolovich will have eyes on an upset. The Trojans are favored by 8.5-points in the latest USC vs. Washington State odds from Caesars Sportsbook, and the over-under is set at 62. Before entering any Washington State vs. USC picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Washington State vs. USC. You can head to SportsLine to see its picks. Here are several college football odds for USC vs. Washington State:

  • USC vs. Washington State spread: USC -8.5
  • USC vs. Washington State over-under: 62 points
Featured Game | Washington State Cougars vs. USC Trojans

What you need to know about Washington State

Washington State didn't have too much trouble with the Portland State Vikings at home last Saturday as the Cougars won 44-24. Washington State QB Jayden de Laura was slinging it as he passed for two TDs and 284 yards on 26 attempts in addition to punching in one rushing touchdown.

The Cougars' defense is giving up 430.5 yards per game through its first two weeks but have been opportunistic, using four turnovers to help limit opponents to 25.0 points per game. However, the Washington State defense has only managed two sacks in two weeks and it will have to create more pressure to take advantage of the tumult at USC.

What you need to know about USC

Meanwhile, the Trojans might not have won anyway, but with 94 yards lost due to penalties, they really shot themselves in the foot last Saturday. They came up short against the Stanford Cardinal, falling 42-28. USC was down 35-13 at the end of the third quarter, which was just too much to recover from. No one had a standout game offensively for USC, but the Trojans got scores from WR Drake London, RB Keaontay Ingram, and RB Darwin Barlow.

The Trojans did beat Washington State 38-13 a season ago despite managing only five yards rushing in the contest. The USC defense forced three turnovers in that game and Kedon Slovis went 25-of-32 for 287 yards and five touchdowns in the victory. Slovis will have to lead by example again with USC in transition.

How to make Washington State vs. USC picks

The model has simulated USC vs. Washington State 10,000 times and the results are in. We can tell you that the model is leaning over and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins USC vs. Washington State? And which side of the spread is a must-back? Visit SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.