The East Carolina Pirates will look to snap a two-game losing streak when they take on the visiting South Florida Bulls in American Athletic Conference action on Thursday night. The Pirates (3-4, 1-2) have played well at home this season, going 2-1 after posting a 3-7 on their home field the previous two years. The Bulls (2-5, 1-2) are 0-8 on the road over the past two years. USF is coming off a 34-14 win over Temple, which snapped a 13-game conference losing streak.

Kickoff from Dowdy-Ficklen Stadium in Greenville, N.C., will be at 7:30 p.m. ET. Both teams have been adequate in taking care of the football, and are tied for 55th in the nation with a plus-one turnover margin. The Pirates are favored by 9.5 points in the latest USF vs. East Carolina odds from Caesars Sportsbook, while the over-under for total points scored is 56. Before making any East Carolina vs. South Florida picks, check out the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,900 for $100 players on its top-rated college football picks against the spread. It also enters Week 9 of the 2021 season on a 26-11 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Florida vs. East Carolina and locked in its coveted picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and betting lines for ECU vs. USF:

  • USF vs. East Carolina spread: ECU -9.5
  • USF vs. East Carolina over-under: 56 points 
  • USF vs. East Carolina money line: South Florida +300, East Carolina -380
  • USF: The Bulls are 6-2 against the spread against a team with a losing record 
  • ECU: The Pirates are 5-0 ATS in their last five conference games
Featured Game | East Carolina Pirates vs. South Florida Bulls

Why East Carolina can cover

Redshirt junior quarterback Holton Ahlers looks to even his career record against South Florida at 2-2. The left-hander is scheduled to make his 33rd collegiate start. In three previous appearances against the Bulls, Ahlers has passed for 442 yards and three touchdowns. He ran for 48 yards and a score as a freshman in the 2018 game in Tampa, Fla. For the season, Ahlers has completed 60.3 percent of his passes, completing 144 of 239 for 1,763 yards and 10 touchdowns.

Defensively, the Pirates are led by redshirt sophomore Ja'Quan McMillian. He leads the team with 41 tackles, including 28 solo, with 12 pass breakups and four interceptions, including one he returned for a touchdown. He has also recovered one fumble. He's had two games with 10 tackles -- the season opener against Appalachian State and against Charleston Southern in Week 4.

Why South Florida can cover 

Freshman quarterback Timmy McClain has been impressive this season. He has completed 74 of 130 passes (56.9 percent) for 1,000 yards and two touchdowns. He has been picked off twice and has a rating of 123.5. McClain is a dual threat, rushing 74 times for 217 yards (2.9 average) and one touchdown. In last week's win over Temple, McClain completed 10 of 13 passes (76.9 percent) for 71 yards and one touchdown.

Defensively, South Florida is led by redshirt sophomore safety Matthew Hill. Hill has 42 tackles, including 28 solo, with one pass breakup and one interception he returned 27 yards. His best game was Oct. 2 at SMU, when he made 11 tackles, including nine solo. The transfer from Auburn has 46 career tackles, including 30 solo.

How to make South Florida vs. East Carolina picks

SportsLine's model is leaning over on the point total, projecting 57 combined points. The model has also generated an against-the-spread pick that cashes in well over 50 percent of simulations. You can only get the model's East Carolina vs. South Florida picks at SportsLine

So who wins South Florida vs. East Carolina? And which side of the spread cashes in well over 50 percent of simulations? Visit SportsLine now to see which side of the East Carolina vs. USF spread to jump on, all from the advanced model that has crushed its college football picks, and find out.