Get ready for an ACC battle as the Virginia Tech Hokies and the Syracuse Orange will face off at 12:30 p.m. ET on Saturday at Lane Stadium. Virginia Tech is 3-3 overall and 3-2 at home, while Syracuse is 3-4 overall and 1-1 on the road. The ACC teams who were also formerly in the Big East together have played 18 times, with Syracuse holding a 10-8 advantage in the all-time series.

However, they've only played once in the last 18 years (2016) and it's Syracuse that is 6-1 against the spread this season, while Virginia Tech is just 2-4. The Hokies are favored by three points in the latest Virginia Tech vs. Syracuse odds from Caesars Sportsbook and the over-under is set at 45.5. Before entering any Syracuse vs. Virginia Tech picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia Tech vs. Syracuse. You can head to SportsLine to see its picks. Here are several college football odds for Syracuse vs. Virginia Tech:

  • Virginia Tech vs. Syracuse spread: Virginia Tech -3
  • Virginia Tech vs. Syracuse over-under: 45.5 points
Featured Game | Virginia Tech Hokies vs. Syracuse Orange

What you need to know about Virginia Tech

The Hokies took a 28-7 defeat to the Pittsburgh Panthers last week. Virginia Tech was in a tough position by the half, with the score already sitting at 21 to nothing. QB Braxton Burmeister wasn't much of a difference maker for Virginia Tech. He threw one interception and only average 4.19 yards per passing attempt.

Virginia Tech has averaged just 3.5 yards per carry so far this season and that lack of versatility has put a lot of pressure on Burmeister and the passing game. The Hokies defense has been solid though, allowing just 351.8 yards and 20.2 points per game so far this season.

What you need to know about Syracuse

Meanwhile, it was a hard-fought game, but Syracuse had to settle for a 17-14 defeat against the Clemson Tigers last Friday. Despite the loss, the Orange got a solid performance out of RB Sean Tucker, who picked up 157 yards on the ground on 22 carries. Tucker has now rushed for 948 yards and nine touchdowns while adding 14 catches for 224 yards and two more scores.

Quarterback Garrett Shrader has also helped Syracuse establish a successful rushing attack as he's rushed for 418 yards and nine touchdowns. The combination of Shrader and Tucker will make it difficult for Virginia Tech to establish its run fits and if they can get both players going early, Saturday could be a challenge for the Hokies.

How to make Syracuse vs. Virginia Tech picks

The model is leaning over on the total and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Virginia Tech vs. Syracuse? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to see which side to back, all from the model that has crushed its college football picks.