This week's first ACC football matchup will be between undefeated Wake Forest (3-0) and Virginia (2-1). The Cavaliers will host the Demon Deacons on Friday as part of a four-game FBS slate. Wake Forest has fielded one of this year's best defenses. It should be challenged by Virginia's dynamic passing attack, though.

Kickoff at Scott Stadium is set for 7:30 p.m. ET. The Cavaliers are 3.5-point favorites in the latest Wake Forest vs. Virginia odds from Caesars Sportsbook. The over-under for total points is set at 70. Before locking in any Virginia vs. Wake Forest picks, make sure you see the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Wake Forest vs. Virginia. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Virginia vs. Wake Forest:

  • Wake Forest vs. Virginia spread: Virginia -3.5
  • Wake Forest vs. Virginia over-under: 70 points 
  • Wake Forest vs. Virginia money line: Virginia -160, Wake Forest +140
  • WF: The Demon Deacons are 5-0 against the spread in their last five games against Virginia 
  • UVA: The Cavaliers 5-0 against the spread in their previous five home games
Featured Game | Virginia Cavaliers vs. Wake Forest Demon Deacons

Why Wake Forest can cover

Virginia hasn't had an answer for Wake Forest lately. The Demon Deacons have taken down the Cavaliers in four consecutive games. While Virginia only lost one home game during that span, Wake Forest has won by an average of more than 10 points since 2008.

The Demon Deacons have been outstanding on defense. They've given up fewer than 14 points per game through three weeks and have forced nine turnovers. Only Boise State has more takeaways than Wake Forest. Stealing a possession or two from Virginia's dominant offense could help the underdogs cover.

Why Virginia can cover

Opponents can't keep Virginia out of the end zone in 2021. The Cavaliers are averaging 41.3 points per game, and star quarterback Brennan Armstrong drives the Cavaliers' impressive passing game. Armstrong is second among all FBS quarterbacks in passing yards (1,298) and helped Virginia secure a lead over No. 21 North Carolina last week.

The Cavaliers have only lost one home game since the 2019-20 season. The Demon Deacons are just 3-6 on the road since then. Virginia's record at Scott Stadium could make it difficult for Wake Forest to stay close.

How to make Virginia vs. Wake Forest picks

SportsLine's model is leaning under on the total, projecting the teams to combine for 68 points. The model also says one side of the spread hits in over 60 percent of simulations. You can only get the pick at SportsLine

So who wins Wake Forest vs. Virginia? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.