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No. 2 Alabama will likely need to win out to make an appearance in this year's College Football Playoff. It certainly cannot afford to slip up against No. 21 Arkansas on Saturday afternoon in the 3:30 p.m. ET SEC on CBS matchup. The Crimson Tide are 20.5-point favorites over the Razorbacks in the latest Week 12 college football odds at Caesars Sportsbook. Alabama has already been upset once this season, so should you be backing Arkansas in this game?

The Razorbacks are coming off consecutive wins over LSU and then-No. 17 Mississippi State. They were blown out by top-ranked Georgia earlier this year, though, so they might be one of the Week 12 college football spreads to avoid. Which lines should you build your Week 12 college football parlays around? Before locking in any college football bets, be sure to see the top Week 12 college football expert picks, predictions and best bets from Barrett Sallee.

Sallee is a true insider -- a CBS Sports analyst, SiriusXM host, Heisman voter and consistently one of the top CBS Sports experts picking games against the spread -- and his best bets have helped bring in huge returns. He debuted with SportsLine in 2017 and has delivered in a big way on his college football picks

Over the past two-plus years, he is 95-75 in his popular best bets column at SportsLine. Anybody who has been following him is way up.

Now, he has turned his attention to the Week 12 college football odds from Caesars and is sharing his top three best bets over at SportsLine. If you parlay them together, you could be looking at a return of around 6-1. Get his top college football picks now

Top Week 12 college football expert predictions

One of Sallee's top college football picks for Week 12: He's backing No. 10 Wake Forest (+4.5) at Clemson in a noon ET kickoff in the ACC. 

The Demon Deacons have a chance to clinch the ACC Atlantic Division title on Saturday afternoon. They have been one of the highest-scoring teams in the country, averaging 44.7 points per game. Quarterback Sam Hartman ranks eighth nationally with 30 touchdown passes.

Wake Forest is facing a Clemson offense that has struggled under quarterback DJ Uiagalelei. His 107.4 passer rating ranks last in the ACC and he is going to be without his top target on Saturday, as wide receiver Justyn Ross is out with a foot injury. Clemson does not have a single senior starting this game and it only has two juniors making starts. 

"Offenses drive the bus in college football, and Clemson barely even has one," Sallee told SportsLine. "The Demon Deacons, however, are averaging 6.54 yards per play and can take the ACC Atlantic with a win. Clemson's spread record will get even worse after the Sam Hartman experience rolls through town."

Featured Game | Clemson Tigers vs. Wake Forest Demon Deacons

How to make Week 12 college football picks 

Sallee has also found two other college football picks he's high on, and they're both underdogs he believes will not only cover, but win outright. You can only see his picks at SportsLine.

What are the best bets for Week 12 of college football? And which college football picks need to be part of your parlays? Visit SportsLine now to see Barrett Sallee's college football best bets, all from one of the top analysts in the nation who has crushed his picks for SportsLine.