NCAA Football: Kansas at Oklahoma State
Rob Ferguson / USA TODAY Sports

The West Virginia Mountaineers and the Oklahoma State Cowboys are set to square off in a Big 12 battle at 3:30 p.m. ET on Saturday at Milan Puskar Stadium. The Mountaineers are 4-4 overall and 3-1 at home, while Oklahoma State is 7-1 overall and 2-1 on the road. This will be the 13th all-time meeting between the two programs. 

The Cowboys have won six in a row in the series and covered in all of those games. However, West Virginia is 8-1-1 in its last 10 games at home. The Cowboys are favored by 3.5-points in the latest West Virginia vs. Oklahoma State odds from Caesars Sportsbook, and the over-under is set at 49. Before entering any Oklahoma State vs. West Virginia picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on West Virginia vs. Oklahoma State. You can head to SportsLine to see its picks. Here are several college football odds for West Virginia vs. Oklahoma State:

  • West Virginia vs. Oklahoma State spread: WVU +3.5
  • West Virginia vs. Oklahoma State over-under: 49 points
Featured Game | West Virginia Mountaineers vs. Oklahoma State Cowboys

What you need to know about West Virginia

The Mountaineers are coming off a thrilling upset of an Iowa State program where Jarret Doege lit it up through the air and the defense made things tough on Brock Purdy. West Virginia won 38-31 with Doege passing for 370 yards and three touchdowns, while running back Leddie Brown added 109 yards on the ground and two scores.

West Virginia held Purdy to 16-of-27 passing for just 185 yards on the day and now it will look to similarly frustrate Spencer Sanders, who has been a little uneven this season. Mountaineers linebacker Josh Chandler-Semedo had 12 tackles and a sack in the victory and he'll have to make plays from sideline-to-sideline again for West Virginia to earn its second upset against a ranked opponent in as many weeks.

What you need to know about Oklahoma State

Meanwhile, Oklahoma State ran circles around the Kansas Jayhawks last Saturday, and the extra yardage (534 yards vs. 143 yards) paid off. Oklahoma State was completely in charge, breezing past Kansas 55-3 at home. It was a big night for Cowboys QB Spencer Sanders, who passed for two touchdowns and 157 yards on 19 attempts in addition to rushing for one score and 53 yards.

The blowout meant that Jaylen Warren only received nine carries in the game but he still turned in 69 yards and has now rushed for 850 yards and six touchdowns this season. Oklahoma State will have to establish its running game early to open things up for Sanders down the field against a West Virginia defense that is gaining confidence after slowing down Purdy last week.

How to make West Virginia vs. Oklahoma State picks

The model has simulated West Virginia vs. Oklahoma State 10,000 times and the results are in. We can tell you that the model is leaning under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You can only see the pick at SportsLine.

So who wins Oklahoma State vs. West Virginia? And which side of the spread hits well over 50 percent of the time? Visit SportsLine now to find out which side of the spread you need to back, all from the proven computer model that has crushed its college football picks.