Justin Cousin added 14 points for Radford (4-5), which controlled the boards 44-35 and went 16 for 17 from the line.
The Highlanders got a 3-pointer from Cousin in the second half to spark an 11-0 run, which was capped with a 3 from Christian Lutete, and gave Radford the lead for good, 46-39, with 8:24 left to play. Caleb Tanner hit the go-ahead jumper and followed it up with a 3-pointer.
Earlier, Elon (6-4) had used a 12-0 run stretching across both sides of the break to take a 34-31 lead early in the second half on Steven Santa Ana's layup and protected it for nearly six minutes.
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