Hufanga is dealing with a knee sprain and will be evaluated during the week, Eric Branch of the San Francisco Chronicle reports.
The injury knocked Hufanga out of Sunday's win over Atlanta. San Francisco has a short turnaround before facing the Titans on Thursday, which means Hufanga will be facing an uphill battle to suit up. If neither Hufanga nor Jaquiski Tartt (ankle) can go, Jarrod Wilson would slide up to the top of the depth chart at strong safety.