Nelson aggravated a right ankle injury Sunday against the Bills, according to head coach Frank Reich, Mike Chappell of Fox 59 News Indianapolis reports.
Nelson was placed on IR on Oct. 2 with an ankle injury. He was able to return on Nov. 4 against the Jets and has been active since. Reich also added that the injury is something Nelson will likely have to deal with the rest of the season, and the team will need to balance his treatment and playing time. Nelson will try to suit up Sunday against the Buccaneers.