Sharpe (foot) has been ruled out for the remainder of Sunday's game against the 49ers, Tori McElhaney of the Falcons' official site reports.
Sharpe will be unavailable late in Sunday's matchup after he sustained a foot injury in the third quarter. He failed to haul in his lone target prior to his departure. The severity of Sharpe's injury isn't yet clear, but his next chance to return will be Dec. 26 against Detroit.