Joe Burrow has gone from an MVP candidate who ranked fourth in Fantasy points at quarterback last year to someone who may not make the cut for Week 5 Fantasy football lineups in two-quarterback leagues. Burrow sits 31st among quarterbacks in Fantasy points, behind the likes of Derek Carr and Ryan Tannehill. Burrow will face Arizona's 24th-ranked pass defense, so should the Bengals' signal-caller factor move up your Week 5 Fantasy football rankings?

With quarterbacks like Dak Prescott and Russell Wilson playing elite defenses this week and with four teams on bye, Burrow may be higher up the Week 5 Fantasy football QB rankings than expected. Before you lock in your Week 5 Fantasy football picks, be sure to check out the Week 5 Fantasy football rankings from the proven computer model at SportsLine.

The model is powered by the same people who generated projections for all three major Fantasy sites, and it beat human experts last season when there was a big difference in ranking. The 2023 Fantasy football PPR rankings and 2023 Fantasy football standard projections update multiple times daily, so you're always getting the best Fantasy football advice and the latest Fantasy football tiers.

Now, SportsLine has simulated the entire Week 5 NFL schedule 10,000 times and released its latest Week 5 Fantasy football rankings. Head to SportsLine now to see them

Top Week 5 Fantasy football QB rankings

Here's a look at SportsLine's top Week 5 Fantasy football QB picks: 

1. Patrick Mahomes, Kansas City Chiefs: The Kansas City offense is off to a sluggish start, but the two-time NFL MVP still ranks seventh among quarterbacks in Fantasy points per game. Over the last three weeks, he's thrown for 803 yards and seven touchdowns. Mahomes has also supplemented his passing numbers with the most prolific rushing season of his career to date, as he's rushed for 154 yards on the season and is on pace for over 650 on the year.

2. Josh Allen, Buffalo Bills: Like Mahomes, Allen struggled in Week 1, but has bounced back with three consecutive multi-touchdown games. That includes a head-turning performance against the Dolphins last week where he threw for 320 yards and four touchdowns while adding a rushing touchdown. Now, he'll take on a Jaguars defense that ranks 22nd against the pass in Week 5.

3. Tua Tagovailoa, Miami Dolphins: Miami disappointed in Week 4 against Buffalo, but Tua still averaged 8.1 yards per pass attempt and finished with 282 yards and a touchdown. He leads the NFL in passing yards (1,306) and is averaging a staggering 9.6 yards per pass attempt. In Week 5, he'll face a Giants defense that ranks 27th in net yards allowed per pass attempt (6.8). See more top QBs here.

Top Week 5 Fantasy football RB rankings

Here's a look at SportsLine's top Week 5 Fantasy football RB picks: 

1. Christian McCaffrey, San Francisco 49ers: McCaffrey has now started 17 games for the Niners, counting the postseason, and he's scored 20 total touchdowns across those contests. This season, he leads the NFL in rushing yards (459), rushing TDs (six), scrimmage yards (600) and total TDs (seven).

2. Derrick Henry, Tennessee Titans: The two-time rushing champ is coming off his first 100-yard game of the season as he had 133 scrimmage yards and a rushing touchdown, in addition to a two-yard passing TD. He now faces the Colts, and Henry has 100-yard outings in six of his last seven games versus Indy.

3. De'Von Achane, Miami Dolphins: After 230 yards and four TDs in Week 2, Achane had 120 yards and two TDs in Week 3. Additionally, he logged more snaps (39) than Raheem Mostert (28) for the first time last game, so he appears to be Miami's No. 1 RB for the time being. See more top RBs here.

Top Week 5 Fantasy football WR rankings

Here's a look at SportsLine's top Week 5 Fantasy football WR picks: 

1. Tyreek Hill, Miami Dolphins: Hill is coming off what's considered a subpar game with 72 total yards, which would be an average outing for most wide receivers. That's the high bar he's set for himself as he's either scored a TD or had 90-plus yards in 11 of his last 12 games playing alongside Tua Tagovailoa.

2. Davante Adams, Las Vegas Raiders: Adams temporarily left last week's game with a shoulder injury but returned and finished with eight catches for 75 yards. Despite missing some snaps, he was targeted five times in the redzone, which is as many as he had over the first three games combined. That's an encouraging sign for Week 5, as is Adams wanting to have a great performance against his former team in the Packers.

3. Stefon Diggs, Buffalo Bills: With at least six receptions in every game, Diggs is as consistent as they come. He's gone over 100 yards in three of four games and is coming off the fourth three-touchdown game of his career. See more top WRs here.

Top Week 5 Fantasy football TE rankings

Here's a look at SportsLine's top Week 5 Fantasy football TE picks:

1. Travis Kelce, Kansas City Chiefs: Despite missing a game and playing limited snaps in Weeks 2 and 3, Kelce still ranks sixth at his position in Fantasy points. He remains the top target in one of the league's most explosive offenses, a superlative we know all too well. He now gets a Fantasy-friendly matchup versus a Vikings team that allowed two touchdowns to opposing tight ends over the last two weeks.

2. Mark Andrews, Baltimore Ravens: After missing Week 1, Andrews has racked up more Fantasy points than any other tight end since then. He's coming off a 5-80-2 stat line and faces a Steelers team that he had a nine-catch, 100-yard game against the last time he saw them.

3. Taysom Hill, New Orleans Saints: Even with Alvin Kamara returning from suspension last week, Hill still saw a season-high in snaps and had five touches from scrimmage. His all-purpose abilities have him this high up in the Week 5 Fantasy football TE rankings ahead of a game versus a Patriots defense that allowed 73 yards to tight end Jake Ferguson in the first half alone last week. See more top TEs here.

Top Week 5 Fantasy football defense rankings 

Here's a look at SportsLine's top three Week 5 Fantasy football D/ST picks:

1. Eagles D/ST: Philadelphia only ranks 16th in points allowed and yards allowed, but it has been opportunistic over its first three weeks, forcing eight turnovers. That sleeping giant of a pass rush awoke in Week 4 with five sacks. Now, the Eagles will take on a Rams offense that has dropped back a league-leading 166 times and you can expect Philly's pass rushers to have their ears pinned back.

2. Colts D/ST: Indianapolis ranks bottom half of the league in most categories, but is ninth in yards allowed per carry (3.8) and will take on a one-dimensional Titans offense in Week 5. Ryan Tannehill has a QBR of 28.2 with two touchdown passes and four interceptions, so stop running back Derrick Henry and you can shut down Tennessee.

3. Titans D/ST: Indianapolis' offense ranks 23rd in yards per play (4.8) and rookie quarterback Anthony Richardson has only thrown for 479 yards in his three starts. Meanwhile, the Titans are coming off a week in which they limited the Bengals to just 211 yards of total offense. The Titans have only allowed opponents to convert on 32.7% of third-down attempts this season. See more top defenses here.

How to get Week 5 Fantasy football rankings

Now that you know who the top three at each position are, you'll want to see the full Week 5 Fantasy football rankings from SportsLine. The model has identified a stunner in the top five at running back, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 5 Fantasy football rankings

So who should you target in your Week 5 Fantasy football rankings, and which surprising running back could lead you to victory? Visit SportsLine now to get Week 5 Fantasy Football rankings for every single position, all from the model that has crushed experts, and find out.