The nice thing about picking second in just about any format is that you don't have much of a choice to make in Round 1. In 90% of leagues, you're taking Dalvin Cook. If the guy who picks first messes up and you get Christian McCaffrey, all the better. Just know that the easy choices are over after that first pick. Now the real work begins.
Picking at either end presents a challenge because of the distance between your picks and the runs that can happen. It's easy to miss two or three tiers at a position. Also, basically anyone you're considering at 3.2 is certain to be gone when you pick at 5.11. And that happens every two rounds. For that reason, on either end, it's best to just get your guys and worry less about ADP than you normally would. There's no "reaching" when you have to wait 20 picks for your next pick.
Here's my team from No. 2 overall
1.2 Dalvin Cook, RB, MIN
2.11 D'Andre Swift, RB, DET
3.2 Patrick Mahomes, QB, KC
4.11 Ja'Marr Chase, WR, CIN
5.2 Mark Andrews, TE, BAL
6.11 Tee Higgins, WR, CIN
7.2 Robby Anderson, WR, CAR
8.11 Mike Williams, WR, LAC
9.2 Melvin Gordon, RB, DEN
10.11 Tevin Coleman, RB, NYJ
11.2 Terrace Marshall, WR, CAR
12.11 Amon-Ra St. Brown, WR, DET
13.2 Tyrell Williams, WR, DET
14.11 Xavier Jones, RB, LAR
15.2 Joshua Kelley, RB, LAC
It is very unusual for me to go three rounds without a wide receiver in any league that rewards anything for receptions. It would never happen in a full PPR league. But from this draft position, in this format, I feel very uncomfortable taking only one running back in my first three picks. And it's hard to pass up the advantage Mahomes has been over every other quarterback the past three seasons. Among quarterbacks who have played all three seasons, none of them have been within three Fantasy points per game of Mahomes.
Of course, this approach means loading up on pass catchers, and that's exactly what I did with my next five picks. While I'm not sure I found any who are very likely to be No. 1 receivers, I have four who could very easily be No. 2s. And you shouldn't sleep on the upside whoever ends up being Joe Burrow's No. 1 in Cincinnati. He was averaging 40 attempts per game before he got hurt. I'm betting on his college teammate, but I was thrilled to land Higgins, a special talent, two rounds later.
Oddly, I ended up with three pairs of receiver teammates. That was mostly a coincidence, except for the Lions. St. Brown and Tyrell Williams appear to me to be the two most likely to lead the team in targets, and the truth is that one of these Lions receivers is likely to be a Fantasy contributor. Tyrell Williams has familiarity with the coaching staff, but the rookie may be the best route runner already.
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LAC L.A. Chargers • #81
Age: 26 • Experience: 5 yrs.
This is not just my favorite pick because Chris Towers cursed me when I picked him, but that didn't hurt anything. Williams has never had the season we thought he might when the Chargers took him in the first round five years ago, but that's more about target share than efficiency. Williams has been one of the best in the league on a per catch and per-target basis and the new coaching staff keeps talking about getting him the ball more. Devante Parker and Will Fuller have shown us that late breakouts do happen at receiver, it's Williams' turn in 2021.
KC Kansas City • #15
Age: 26 • Experience: 5 yrs.
I don't have any doubt about Mahomes, obviously. But in most people's eyes the opportunity cost is pretty huge here at tight end. Personally, I see a much bigger gap between Mahomes and Dak Prescott, (or Kyler Murray) than I do between Darren Waller (or George Kittle) and Mark Andrews. But I'm in the minority there. if Andrews underperforms my expectations and Prescott or Murray is close to Mahomes, I'll regret taking a quarterback so early.
DET Detroit • #32
Age: 22 • Experience: 2 yrs.
On the positive side, Swift flashed top five upside as a rookie, averaging more than 20 Fantasy points per game when he received at least 15 touches per game. And Anthony Lynn's offenses have historically produced 30 running back touches per game. But, I did take a committee back on a sub-.500 team in Round 2. If Swift lives up to his pedigree (and Lynn's history) I could have a pair of top-10 running backs but there's plenty of risk with this pick.