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Byes are done with for the 2025 NFL season, which means you have a full complement of Week 15 Fantasy football picks to choose from. There are, however, player injuries, which is a season-long thing to deal with when composing a Fantasy football strategy. Nonetheless, the likes of Drake Maye, Jaxson Dart, Christian McCaffrey, George Kittle and Tetairoa McMillan are back in action after being on a bye. But who should start along side them in Week 15 Fantasy football lineups?

Speaking of injuries, Daniel Jones (Achilles) was one of many casualties on Sunday, as those who have been riding him all season long at quarterback are likely seeking out some Week 15 Fantasy football advice. His absence has a ripple effect, and while Jonathan Taylor remains a must-start, where do the Fantasy football projections forecast for Colts pass catchers like Michael Pittman Jr., Alec Pierce and Tyler Warren? Before making your Week 15 Fantasy football picks, be sure to check out the Week 15 Fantasy football rankings from the proven computer model at SportsLine. 

Bet on every NFL Week 15 game at DraftKings Sportsbook, where new users can target the DraftKings promo code, which offers $200 in bonus bets if your $5 initial wager wins:

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons, especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

The same model has a proven track record providing Fantasy football tips, including being ahead of the curve on players like A.J. Brown, Jonathan Taylor, Derrick Henry, Christian McCaffrey, Alvin Kamara and Jahmyr Gibbs. Anybody who banked on players like those could have made a run at their league title.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Week 15 of the 2025 NFL season. Head to SportsLine now to see them. 

New users can also check out the latest FanDuel promo code and get $150 in bonus bets instantly at FanDuel if your $5 bet wins. 

Top Week 15 Fantasy football picks 

One surprise in Week 15: The model is fading Colts tight end Tyler Warren, who ranks third at his position in both receiving yards and in Fantasy points, may not warrant a spot in Week 15 Fantasy football lineups. Warren is a by-product of Indy's passing game, which just lost Daniel Jones (Achilles) for the season, has Anthony Richardson on IR, and has third-strong rookie, Riley Leonard (knee) dealing with his own ailment. Warren had season lows in both catches (2) and yards (15) on Sunday, with Leonard playing most of the game. Not much more is expected on Sunday versus Seattle, which has the No. 2 scoring defense and No. 6 total defense. Warren sits outside the top 15 in Fantasy football TE rankings.

Another curveball: The model is high on Commanders running back Chris Rodriguez Jr., despite him being the RB50 in standard leagues and being started in just 35% of leagues this week. Rodriguez has leapfrogged Jacory Croskey-Merritt on the depth chart, as the former has more touches each of the last three weeks. He hasn't disappointed with more opportunities as Rodriguez has at least 52 scrimmage yards or a touchdown in five straight games. With the Giants' league-worst run defense on tap, as New York allows the most yards per carry and the second-most rushing yards per game, Rodriguez should find his way into your Week 15 Fantasy football lineups. For more start/sit Fantasy football advice, be sure to check out the rest of the Week 15 Fantasy football rankings.

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How to set Week 15 Fantasy football rankings

The model is also calling for a surprising running back you aren't even thinking about to finish in the top 20 of its Week 15 Fantasy football rankings, even slotted ahead the likes of Breece Hall and Ashton Jeanty. This pick could be the difference between winning big and going home with nothing. See the model's entire Week 15 Fantasy football rankings for PPR and standard leagues here.

So who should you start and sit this week, and which surprising running back could lead you to victory? Visit SportsLine now to get Week 15 Fantasy football rankings for every position, plus see which running back is going to come out of nowhere to crack the top 20 all from the model that has outperformed experts big-time.