Two of the hottest running backs in Week 17 will be in action during Wild Card Weekend, as the Colts' Jonathan Taylor takes on the Bills on Saturday, while the Titans' Derrick Henry faces the Ravens on Sunday. Taylor crushed Jacksonville for 253 yards and two touchdowns in Week 17, while Henry locked down his second straight rushing title and 2,000-yard campaign after a 250-yard, two-touchdown outburst against Houston. Buffalo and Baltimore have stouter run defenses, so are Taylor and Henry still smart Fantasy football picks for Wild Card Weekend?

How should Taylor and Henry stack up against other stellar running backs like Alvin Kamara, Nick Chubb and David Montgomery in your Fantasy football rankings? Before you lock in your Fantasy football strategy for the 2021 NFL Playoffs, be sure to check out the Fantasy football rankings for Wild Card Weekend from the proven computer model at SportsLine.

When it comes to ranking players, their model beat human experts in Fantasy football last season when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Vikings quarterback Kirk Cousins, saying he'd finish as a top-five player at his position. The result: Cousins completed 70 percent of his passes for 405 yards and three touchdowns. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its Fantasy football rankings for Wild Card Weekend. Head to SportsLine now to see them.

Top Fantasy football picks for Wild Card Weekend

One player the model is extremely high on this week: Seahawks wide receiver DK Metcalf. The second-year standout from Ole Miss was seventh in the NFL this season with 1,303 receiving yards and eighth with 10 touchdowns. That followed up a rookie season that saw Metcalf haul in 58 passes for 900 yards and seven scores. 

Although Metcalf was checked to just three catches for 21 yards in Week 17 against the Niners, there is no doubt the big-bodied receiver is primed for a huge postseason. He is considered a prime deep threat anytime he takes the field, and SportsLine agrees, ranking Metcalf as a top-five wide receiver on Wild Card Weekend.

And a massive shocker: Browns running back Kareem Hunt, who's accounted for 11 total touchdowns this season, stumbles big-time and doesn't even crack the top 15 at his position. Hunt is coming off a disappointing performance against the Steelers in Week 17, carrying the ball 10 times for 37 yards. 

Hunt has struggled to find his rhythm in Cleveland's rushing attack recently, as he's logged 40 or fewer rushing yards in six of Cleveland's final seven games. He's also recorded just 77 total rushing yards in two games against Pittsburgh this season, one of the main reasons why the model has him ranked outside the top 15 in its Fantasy football running back rankings.

With such a tough matchup on Wild Card Weekend, Hunt is a player to consider putting on the bench.

How to set your Wild Card Weekend Fantasy football lineups

The model is also calling for a surprising wide receiver you aren't even thinking about to finish in the top 10 of its Fantasy football rankings, and his team could be in for a deep run in the playoffs. You can see who it is here.

So who should you start and sit this week? And which surprising wide receiver could lead you to victory? Visit SportsLine now to get Wild Card Weekend Fantasy football rankings for every position, plus see which wide receiver is going to come out of nowhere to crack the top 10, all from the model that out-performed experts big-time last season.