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USA Today

The 2022 NFL playoffs will begin Saturday, and Fantasy football players still trying to get a piece of the action will be treated to a supersized NFL Wild Card Weekend. The league expanded the NFL playoff bracket from 12 teams to 14, which means there are more players to consider for your Fantasy football rankings. Making sure your NFL Wild Card Weekend Fantasy football lineups are optimized is all about finding the best Fantasy football matchups.

Five of the six games this week will be rematches of regular-season matchups, and two will be between divisional-rivals as the Bills host the Patriots and the Rams host the Cardinals. A reliable set of 2022 NFL Wild Card Weekend Fantasy football rankings can help make sure you know exactly who to target. Before locking in your Wild Card Weekend Fantasy football picks, be sure to check out the playoff Fantasy football rankings from the proven computer model at SportsLine.

When it comes to ranking players, SportsLine's model beat human experts in Fantasy football for the past several seasons especially when there were big differences in ranking. Over the course of a season, that could literally be the difference between winning your league or going home empty-handed.

Last week, the model was extremely high on Seahawks running back Rashaad Penny, ranking him as a top-15 player at his position. The result: Penny ran 23 times for 190 yards and a touchdown. Anybody who had him in their lineup was well on their way to a huge week.

Now, the model, which simulates every NFL game 10,000 times, has revealed its 2022 NFL Wild Card Weekend Fantasy football rankings. Head to SportsLine now to see them.

Top 2022 NFL Playoffs Fantasy football picks 

One player the model is high on this week: Raiders wide receiver Hunter Renfrow. The former Clemson star was a fifth-round pick in the 2019 NFL Draft, and he's evolved into one of the premier slot receivers in the league. Renfrow caught 103 passes for 1,038 yards this season and has become a red-zone threat with his body control, strong route-running and reliable hands.

Renfrow was targeted 24 times inside the 20-yard-line this season and wound up catching nine touchdown passes. He's also capable of making defenders miss in space, ranking ninth among receivers in yards after the catch (447). He'll take on a Bengals squad that ranks 26th in pass defense, so look for another big day from Renfrow, who has four touchdown catches in his last three games.

And a massive shocker: Patriots tight end Hunter Henry, who tied for the league lead among NFL tight ends in touchdown catches and finished No. 7 among TEs, stumbles big-time and doesn't even crack the top 10 at his position. 

Henry signed with the Patriots as a free agent this offseason and started his season slowly, but ultimately caught seven touchdowns in a seven-game span. However, he's only caught two touchdowns in the six games since, and both of those came in a Week 15 loss to the Colts. Expect New England to be focused on establishing the run and for Henry to struggle against a stingy Bills defense that he only had one catch against in two games.

How to set 2022 NFL Wild Card Weekend Fantasy football rankings

The model is also calling for an under-the-radar running back to finish in the top five of its Fantasy football rankings, ahead of backs like Leonard Fournette and Ezekiel Elliott. This pick could be the difference between winning big and going home with nothing. You can only see who it is here.

So who should you start and sit this week? And which surprising running back could lead you to victory? Visit SportsLine now to get NFL playoff Fantasy football rankings for every position, plus see which QB is going to come out of nowhere to crack the top three, all from the model that has out-performed experts big-time.