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Welcome to Week 2, or as I like to call it, "Overreaction Week!" 

It's hard not to overreact after the first games for most of these players in nine months, and you probably need to overreact to at least a certain extent -- being passive around early-season trends can leave you behind the pack. Your opinions on players shouldn't necessarily shift dramatically after an offseason of research, but there's a lot of value in being able to identify where our preseason expectations were just flat out wrong and knowing how to react to that. 

Today's newsletter is all about re-establishing expectations as well as helping you make the right moves to react to what we just saw in Week 1. But first, a quick rundown of all of the Week 1 injuries we'll need to keep an eye on this week:

  • Raheem Mostert (knee) -- Mostert is expected to miss about eight weeks a cartilage injury in his right knee. More about his replacements in the waiver-wire section. 
  • Jerry Jeudy (ankle) -- We're still waiting for a firm diagnosis, but it is believed to be a high-ankle sprain, which usually carries with it at least a multi-week absence. But his season is not over, thankfully. 
  • Ryan Fitzpatrick (hip) -- It seems like we're going to be counting this absence in months, not weeks. Taylor Heinicke figures to step in as the starting QB.
  • Michael Gallup (calf) -- Gallup was placed on IR and will miss at least three weeks -- and the injury could stretch as long as five. 
  • Rashaad Penny (calf) -- Penny has been dealing with this injury for a little while and is expected to be shut down for a few weeks, per reports. Alex Collins will be the primary backup to Chris Carson

For more on the latest news, make sure you tune in to Fantasy Football Today on CBS Sports HQ at noon ET, and for help locking in your waiver-wire claims join Jamey Eisenberg, Adam Aizer, and I on the FFT YouTube stream tonight at 8 p.m., where we'll be taking your questions live for an hour. And, if you want to take one last look back at Week 1 before you move ahead, check out my Week 1 Winners and Losers column here, where I break down every game, including Monday's wild game between the Raiders and Ravens.

Here's what we've got on tap:

  • ➕Top Week 2 Waiver Wire Targets
  • 📈Week 2 Rankings📉

➕Top Week 2 Waiver Wire Targets

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Sep 13, 2020; Jacksonville, Florida, USA; Indianapolis Colts running back Nyheim Hines (21) runs the ball in for a touchdown during the first quarter against the Jacksonville Jaguars at TIAA Bank Field. Douglas DeFelice / USA TODAY Sports

There is going to be a frenzy on the waiver wire ahead of Week 2, and you need to know how to best allocate your resources. Jamey Eisenberg's Waiver Wire column is up and ready for you to get all the help you need. Here are the top targets for this first waiver run of the regular season: 

Jamey Eisenberg's top targets

  1. Elijah Mitchell (6% rostered) -- Mitchell took over after Mostert's injury in Week 1 and looked great in his NFL debut. He figures to be the lead back moving forward, though don't drop fellow rookie Trey Sermon just yet -- he'll probably be active in Week 2. Mitchell may require 40% of your FAB budget to acquire, but unless I'm desperate for a No. 2 RB, I'd probably pass at that price. He's fine for 25%. 
  2. Nyheim Hines (65%) -- Full disclosure: Hines was also one of the top waiver targets coming out of Week 1 last season too when he had seven carries for 28 yards and a touchdown on the ground along with eight catches on eight targets for 45 yards and a score. But this time is different ... right?
  3. Mike Williams (63%) -- Williams has shown flashes, but never quite like what he did in Week 1 when the Chargers used him like more than just a deep threat and he responded with a big performance. He could be in line for a huge breakout. 
  4. Sterling Shepard (29%) -- I'm not quite sure I buy Shepard being able to remain a starting-caliber Fantasy option as the rest of the Giants offense gets healthy, but he was clearly undervalued coming into the season.  
  5. Juwan Johnson (3%) -- Johnson caught two touchdowns in Week 1, but didn't play a huge role otherwise. Hopefully that changes moving forward, but make sure to check if he has TE eligibility in your league before adding him; he doesn't have much appeal otherwise. 

One (more) target for each position

  • QB: Tyrod Taylor (9%) -- Taylor looked pretty great in Week 1, albeit against a very soft Jaguars defense. Still, his rushing abilities make him a No. 2 Fantasy QB. 
  • RB: Mark Ingram (32%) -- It took a perfect storm to get Ingram to an RB19 finish in Week 1, but he's a lead back on a run-first team, so he should be on someone's roster. 
  • WR: Tim Patrick (9%) -- My initial reaction to Jeudy's injury was to add KJ Hamler, and while I still like him, I think I'd prioritize Patrick, who had a seven-game stretch in 2020 where he put up a 16-game pace of 69-1166-7. He's better than you think.
  • TE: David Njoku (2%) -- Njoku played a surprisingly big role in Week 1 and looked really good, earning a handful of deep targets and leading the tight end position with 92 air yards. He ran more routes than Austin Hooper and could emerge as the better Fantasy option of the two. 

📈Week 2 Rankings Preview📉

NFL: Indianapolis Colts at Jacksonville Jaguars
Sep 13, 2020; Jacksonville, Florida, USA; Jacksonville Jaguars running back James Robinson (30) is grabbed on the ankle by Indianapolis Colts middle linebacker Anthony Walker (54) as defensive tackle DeForest Buckner (99) and defensive end Justin Houston (50) and Jaguars center Brandon Linder (65) look on during the first quarter at TIAA Bank Field. Reinhold Matay / USA TODAY Sports

I try not to be too reactionary coming off Week 1, but I'll try to highlight the biggest movers at each position. I've also written about many of the players and my justifications for their rankings at each position, so click on each position for more of my thoughts. Those pages will also be updated throughout the week, so keep the links handy. These are all for PPR leagues:

Quarterbacks

The thing about quarterback is, there's a clear top 10 at the position, and they really stand out right now. Beyond them, you're talking about a point in my projections separating No. 12 from No. 23. Which means there is going to be a lot of movement from one week to the next, without a player's value actually changing. That being said, Jameis Winston and Teddy Bridgewater are big risers, while I'm feeling pretty pessimistic about Ben Roethlisberger and Carson Wentz after Week 1. For more of my thoughts on the quarterback rankings, head here

  1. Lamar Jackson
  2. Patrick Mahomes
  3. Russell Wilson
  4. Josh Allen
  5. Tom Brady
  6. Kyler Murray
  7. Dak Prescott
  8. Aaron Rodgers
  9. Jalen Hurts
  10. Justin Herbert
  11. Matthew Stafford
  12. Ryan Tannehill
  13. Kirk Cousins
  14. Joe Burrow
  15. Derek Carr
  16. Jameis Winston
  17. Tua Tagovailoa
  18. Taylor Heinicke
  19. Baker Mayfield
  20. Tyrod Taylor
  21. Teddy Bridgewater
  22. Matt Ryan
  23. Mac Jones
  24. Sam Darnold
  25. Jimmy Garoppolo
  26. Andy Dalton
  27. Trevor Lawrence
  28. Carson Wentz
  29. Jared Goff
  30. Ben Roethlisberger
  31. Zach Wilson
  32. Daniel Jones

Running backs

Joe Mixon confirmed all of my expectations in Week 1, so while he may be moving up for everyone else, he stays put at RB4 for me. Austin Ekeler hasn't really moved down yet, but if he doesn't get involved in the passing game this week, I'm going to start panicking. I came away from Week 1 pretty pleased with Clyde Edwards-Helaire's role, and a healthy D'Andre Swift looks like he might be the best pick in Fantasy this season. On the opposite end, I dropped James Robinson from the top-12 to fringe No. 2 status, and he could fall further than that. For more of my thoughts on the running back rankings, head here

  1. Christian McCaffrey
  2. Alvin Kamara
  3. Dalvin Cook
  4. Joe Mixon
  5. Najee Harris
  6. Aaron Jones
  7. Austin Ekeler
  8. Nick Chubb
  9. Derrick Henry
  10. Clyde Edwards-Helaire
  11. Antonio Gibson
  12. Chris Carson
  13. Jonathan Taylor
  14. D'Andre Swift
  15. David Montgomery
  16. Ezekiel Elliott
  17. Saquon Barkley
  18. Myles Gaskin
  19. Darrell Henderson
  20. Kareem Hunt
  21. Miles Sanders
  22. Mike Davis
  23. James Robinson
  24. Chase Edmonds
  25. Melvin Gordon
  26. Jamaal Williams
  27. Josh Jacobs
  28. Devin Singletary
  29. Elijah Mitchell
  30. Damien Harris
  31. Javonte Williams
  32. Kenyan Drake
  33. Nyheim Hines
  34. Latavius Murray
  35. Leonard Fournette
  36. J.D. McKissic
  37. Ty'Son Williams
  38. James Conner
  39. James White
  40. David Johnson
  41. A.J. Dillon
  42. Ronald Jones
  43. Mark Ingram
  44. Tevin Coleman
  45. Giovani Bernard
  46. Cordarrelle Patterson
  47. Carlos Hyde
  48. Michael Carter
  49. Tony Pollard
  50. Trey Sermon
  51. Kenneth Gainwell
  52. Ty Johnson
  53. Tony Jones
  54. Larry Rountree
  55. Jeremy McNichols
  56. Malcolm Brown
  57. Phillip Lindsay
  58. Damien Williams
  59. Darrel Williams
  60. Devontae Booker

Wide receivers

Wide receiver rankings shouldn't fluctuate quite as much as running back after one week, because WR usage tends to fluctuate from week to week without necessarily indicating a change in value or role. That being said, I'm more confident in DJ Chark, DeVonta Smith, Jaylen Waddle and Ja'Marr Chase this week, and I'm less confident in Julio Jones, Terry McLaurin, and Robby Anderson. For more of my thoughts on the wide receiver rankings, head here

  1. Davante Adams
  2. Tyreek Hill
  3. DeAndre Hopkins
  4. Stefon Diggs
  5. Calvin Ridley
  6. Allen Robinson
  7. Tyler Lockett
  8. D.K. Metcalf
  9. Amari Cooper
  10. A.J. Brown
  11. Justin Jefferson
  12. Keenan Allen
  13. Cooper Kupp
  14. Chris Godwin
  15. CeeDee Lamb
  16. Robert Woods
  17. D.J. Moore
  18. Mike Evans
  19. Antonio Brown
  20. Julio Jones
  21. Deebo Samuel
  22. Terry McLaurin
  23. Diontae Johnson
  24. Adam Thielen
  25. Corey Davis
  26. Brandin Cooks
  27. Mike Williams
  28. Jarvis Landry
  29. Jaylen Waddle
  30. Ja'Marr Chase
  31. DJ Chark
  32. Robby Anderson
  33. Sterling Shepard
  34. DeVonta Smith
  35. Jakobi Meyers
  36. Tee Higgins
  37. Courtland Sutton
  38. JuJu Smith-Schuster
  39. Will Fuller
  40. Kenny Golladay
  41. Marquise Brown
  42. Tyler Boyd
  43. Laviska Shenault
  44. Mecole Hardman
  45. Chase Claypool
  46. Brandon Aiyuk
  47. Marvin Jones
  48. Emmanuel Sanders
  49. Tim Patrick
  50. Cole Beasley
  51. Marquez Callaway
  52. Bryan Edwards
  53. Michael Pittman
  54. Devante Parker
  55. Rondale Moore
  56. Sammy Watkins
  57. Marquez Valdes-Scantling
  58. Henry Ruggs
  59. Darnell Mooney
  60. Nelson Agholor

Tight ends

The big question at the position after Week 1 is whether T.J. Hockenson is truly ready to join the elite of the position. I'll need to see more, but it was a heck of a start. I'm not at all concerned about Kyle Pitts or Mark Andrews, but I do have some concerns about Jonnu Smith after his disappointing usage in Week 1. For more of my thoughts on the tight end rankings, head here

  1. Travis Kelce
  2. Darren Waller
  3. George Kittle
  4. T.J. Hockenson
  5. Mark Andrews
  6. Kyle Pitts
  7. Logan Thomas
  8. Tyler Higbee
  9. Jonnu Smith
  10. Noah Fant
  11. Rob Gronkowski
  12. Dallas Goedert
  13. Hunter Henry
  14. Austin Hooper
  15. Jared Cook
  16. Robert Tonyan
  17. Will Dissly
  18. Zach Ertz
  19. David Njoku
  20. Juwan Johnson
  21. Tyler Kroft
  22. Anthony Firkser
  23. Cole Kmet
  24. Dalton Schultz
  25. Blake Jarwin
  26. Adam Trautman
  27. Kyle Rudolph
  28. Gerald Everett
  29. Mike Gesicki
  30. Hayden Hurst

Top-150 Flex Rankings

  1. Christian McCaffrey
  2. Alvin Kamara
  3. Dalvin Cook
  4. Joe Mixon
  5. Davante Adams
  6. Tyreek Hill
  7. DeAndre Hopkins
  8. Stefon Diggs
  9. Najee Harris
  10. Aaron Jones
  11. Austin Ekeler
  12. Travis Kelce
  13. Nick Chubb
  14. Derrick Henry
  15. Calvin Ridley
  16. Clyde Edwards-Helaire
  17. Antonio Gibson
  18. Chris Carson
  19. Darren Waller
  20. Jonathan Taylor
  21. Allen Robinson
  22. D'Andre Swift
  23. David Montgomery
  24. Tyler Lockett
  25. Ezekiel Elliott
  26. D.K. Metcalf
  27. Amari Cooper
  28. Saquon Barkley
  29. A.J. Brown
  30. Justin Jefferson
  31. Keenan Allen
  32. Cooper Kupp
  33. Chris Godwin
  34. CeeDee Lamb
  35. George Kittle
  36. Myles Gaskin
  37. Robert Woods
  38. Darrell Henderson
  39. D.J. Moore
  40. Mike Evans
  41. Kareem Hunt
  42. Miles Sanders
  43. Mike Davis
  44. Antonio Brown
  45. Julio Jones
  46. Deebo Samuel
  47. Terry McLaurin
  48. James Robinson
  49. Diontae Johnson
  50. Adam Thielen
  51. Corey Davis
  52. T.J. Hockenson
  53. Brandin Cooks
  54. Chase Edmonds
  55. Mike Williams
  56. Jarvis Landry
  57. Melvin Gordon
  58. Jaylen Waddle
  59. Ja'Marr Chase
  60. DJ Chark
  61. Robby Anderson
  62. Mark Andrews
  63. Sterling Shepard
  64. DeVonta Smith
  65. Kyle Pitts
  66. Jakobi Meyers
  67. Tee Higgins
  68. Jamaal Williams
  69. Josh Jacobs
  70. Devin Singletary
  71. Courtland Sutton
  72. JuJu Smith-Schuster
  73. Elijah Mitchell
  74. Will Fuller
  75. Kenny Golladay
  76. Marquise Brown
  77. Tyler Boyd
  78. Laviska Shenault
  79. Damien Harris
  80. Mecole Hardman
  81. Chase Claypool
  82. Javonte Williams
  83. Kenyan Drake
  84. Logan Thomas
  85. Brandon Aiyuk
  86. Marvin Jones
  87. Emmanuel Sanders
  88. Nyheim Hines
  89. Latavius Murray
  90. Tim Patrick
  91. Cole Beasley
  92. Marquez Callaway
  93. Tyler Higbee
  94. Leonard Fournette
  95. Jonnu Smith
  96. Bryan Edwards
  97. Noah Fant
  98. Michael Pittman
  99. Devante Parker
  100. Rondale Moore
  101. Rob Gronkowski
  102. J.D. McKissic
  103. Sammy Watkins
  104. Ty'Son Williams
  105. James Conner
  106. Marquez Valdes-Scantling
  107. James White
  108. Henry Ruggs
  109. Darnell Mooney
  110. Nelson Agholor
  111. AJ Green
  112. Jalen Reagor
  113. David Johnson
  114. A.J. Dillon
  115. Hunter Henry
  116. Dallas Goedert
  117. Darius Slayton
  118. Christian Kirk
  119. Austin Hooper
  120. Ronald Jones
  121. Elijah Moore
  122. Jared Cook
  123. Robert Tonyan
  124. Gabriel Davis
  125. Mark Ingram
  126. Russell Gage
  127. Will Dissly
  128. David Njoku
  129. Juwan Johnson
  130. Tevin Coleman
  131. Giovani Bernard
  132. Cordarrelle Patterson
  133. Dyami Brown
  134. Carlos Hyde
  135. Terrace Marshall
  136. Zach Ertz
  137. Michael Carter
  138. Tony Pollard
  139. Tyler Kroft
  140. Zach Pascal
  141. Anthony Firkser
  142. Trey Sermon
  143. Dalton Schultz
  144. Parris Campbell
  145. Blake Jarwin
  146. Allen Lazard
  147. Adam Trautman
  148. Kenneth Gainwell
  149. Cole Kmet
  150. Demarcus Robinson

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 2 rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.