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More significant injuries and bye week needs are major factors to consider as we look ahead to Week 5 of the Fantasy football season. Patriots running back Damien Harris came off injured reserve and rushed for 100 yards on Monday night. Should Harris be among your top Week 5 Fantasy football waiver wire picks? In the second game of the night, Packers running back Jamaal Williams caught all eight of his targets for 95 yards. Should he one of your primary Week 5 NFL Fantasy Football waiver wire targets?

Which players on Fantasy football waivers are worth grabbing? And who should you prioritize in your claim order or with your budget? Before you determine who you should target on the Week 5 Fantasy football waiver wire, you need to see what SportsLine's Scott Engel has to say.

Engel is an inaugural member of the Fantasy Sports Writers Association's Hall of Fame. He is a four-time FSWA Award Winner and nine-time finalist, and has pulled off a three-peat in his prestigious New York City Fantasy Football League that includes other experts and high-stakes players. Engel is 45-15 in his seasonal Fantasy football leagues after four weeks. 

He also recommended Green Bay tight end Robert Tonyan, who caught three TD passes on Monday night, as a top waiver target ahead of Week 4. If there's anyone who knows what it takes to win a league, it's him. 

Now, he's revealed the best widely available Fantasy football free agents entering Week 5. You can see his top Fantasy NFL waiver wire picks and full analysis over at SportsLine

Top Fantasy football waiver wire picks for Week 5

One player Engel is advising Fantasy players to target on the Week 5 waiver wire: Chargers quarterback Justin Herbert. In Week 5, Fantasy players will be without Aaron Rodgers, Cam Newton, Matthew Stafford and possibly Josh Allen. Herbert has already proven he can be a capable fill-in in such situations, and deserves regular streaming consideration. In his third start of the 2020 season on Sunday, he scored 28 Fantasy points, his highest output so far. Herbert did not shy away from trading offensive punches with Tom Brady, as he passed for 290 yards and three touchdowns.

In his first start of the year, Herbert responded admirably on short notice in Week 2. He threw for 311 yards with a passing TD and ran for a score against Kansas City. He then passed for 330 yards vs. Carolina in Week 3. Herbert was not expected to start this early in the season but he has seized an opportunity and may not relinquish the job. Not only can he be a quality bye-week plugger, he could settle in as a consistent Fantasy starter if he continues to build on his first few outings.

Another waiver wire target he's all over entering Week 3: Herbert's teammate, running back Justin Jackson. Austin Ekeler could be out for awhile because of knee and hamstring issues, and Jackson may have to step in and take over part of a time share with rookie Joshua Kelley. The team has already given Kelley a healthy workload, but he raised concerns on Sunday. 

Kelley rushed for just nine yards on seven carries, but more alarmingly, he fumbled in a second consecutive game. Los Angeles may not be able to fully trust Kelley as a lead running back, so Jackson could split touches with him and be entrusted with carries on key downs. That could make Jackson a quality flex option during the bye weeks. 

How to set your Week 5 waiver wire claims

Engel is also all-in on an overlooked receiver who should be an immediate add if another team in your league has given up on him. This player is still widely available and could be a huge boost to your Fantasy football roster moving forward. You can only see who it is at SportsLine

So which players should you target on the Fantasy football waiver wire before Week 5? And which notable wide receiver could be cut by one of your opponents and will be worthy of an immediate add? Visit SportsLine now to see the best league-winning Fantasy football free agents entering Week 5, all from a Fantasy Hall of Famer, and find out.