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Depending on how you count it, you could argue up to half the league has already had a change in lead running back since Week 1, either due to injury, demotion, or some other factor. Add in that the Saints, Falcons, Jets, and 49ers are on bye in Week 6 -- so no Alvin Kamara, Mike Davis Cordarrelle Patterson, Michael Carter, or Elijah Mitchell -- and the position looks even shallower than usual this week. And on Friday afternoon, we found out Nick Chubb (calf) and Christian McCaffrey (hamstring) aren't playing Sunday. The hits just keep coming.

Kareem Hunt vaults into the top 10 at running back and lands at No. 5 for me, with the expectation that he should be good for nearly 20 carries and a healthy passing game workload. D'Ernest Johnson also figures to see some run, and Demetric Felton could be a sneaky PPR play if they decide to use Hunt more like they do Chubb and Felton sees more snaps in passing situations. But you'll want Hunt in your lineup, obviously. 

As for McCaffrey's replacement, we know it'll be Chuba Hubbard, and his play so far has been a bit of a mixed bag. In Hubbard's first start, he ceded a bunch of valuable passing game work and had a really disappointing performance despite 15 carries. In his second, he carried the ball 24 times and had six targets. Let's call it in the middle and call him pretty much a must-start Fantasy RB, ahead of all of the waiver-wire adds like Khalil Herbert, Darrel Williams, and Devontae Booker this week. 

Get your first look at the running back rankings for Week 6 from Chris Towers, including thoughts on some of the most interesting players for this week. To see Jamey Eisenberg, Dave Richard, and Heath Cummings' rankings, make sure you head here. We'll be updating this throughout the week with new notes and rankings as we get news and the rankings get tweaked, so make sure you bookmark the page.    

Week 6 RB Rankings

  1. Najee Harris vs. SEA
  2. Derrick Henry vs. BUF
  3. Austin Ekeler @ BAL
  4. Kareem Hunt vs. ARI
  5. Aaron Jones @ CHI
  6. D'Andre Swift vs. CIN
  7. Joe Mixon @ DET
  8. Ezekiel Elliott @ NE
  9. Dalvin Cook @ CAR
  10. James Robinson vs. MIA
  11. Darrell Henderson @ NYG
  12. Jonathan Taylor vs. HOU
  13. Chuba Hubbard vs. MIN
  14. Chase Edmonds @ CLE
  15. Antonio Gibson vs. KC
  16. Josh Jacobs @ DEN
  17. Khalil Herbert vs. GB
  18. Alex Collins @ PIT
  19. Devontae Booker vs. LAR
  20. Leonard Fournette @ PHI
  21. Myles Gaskin @ JAX
  22. Darrel Williams @ WAS
  23. J.D. McKissic vs. KC
  24. Melvin Gordon vs. LV
  25. Jamaal Williams vs. CIN
  26. Miles Sanders vs. TB
  27. Tony Pollard @ NE
  28. Zack Moss @ TEN
  29. Nyheim Hines vs. HOU
  30. Javonte Williams vs. LV
  31. Devin Singletary @ TEN
  32. Damien Harris vs. DAL
  33. Brandon Bolden vs. DAL
  34. Giovani Bernard @ PHI
  35. James Conner @ CLE
  36. Kenneth Gainwell vs. TB
  37. AJ Dillon @ CHI
  38. Latavius Murray vs. LAC
  39. Jerick McKinnon @ WAS
  40. David Johnson @ IND
  41. Mark Ingram @ IND
  42. Alexander Mattison @ CAR
  43. Kenyan Drake @ DEN
  44. Jeremy McNichols vs. BUF
  45. Sony Michel @ NYG
  46. Royce Freeman vs. MIN
  47. D'Ernest Johnson vs. ARI
  48. Devonta Freeman vs. LAC
  49. Ronald Jones @ PHI
  50. Phillip Lindsay @ IND
  51. Malcolm Brown @ JAX
  52. Carlos Hyde vs. MIA
  53. Deejay Dallas @ PIT
  54. Salvon Ahmed @ JAX
  55. Larry Rountree @ BAL
  56. Peyton Barber @ DEN
  57. Marlon Mack vs. HOU
  58. Justin Jackson @ BAL
  59. Rhamondre Stevenson vs. DAL
  60. J.J. Taylor vs. DAL

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that has out-performed experts big-time.