Watch Now: Week 6 Start 'Em Sit 'Em: Wide Receivers (5:59)

Just as a reminder, NFL Week 6 has four teams on a bye week, so your Fantasy football team will be without Russell Wilson, Justin Herbert, Drew Brees, and Derek Carr this week. Dak Prescott's injury will also keep him out for the rest of the season, so that's two top-five quarterbacks and at least two other starters off the board. 

There's still enough depth at the position, of course, that you probably don't feel too bad about your options, but when you're missing high-end options, that usually means you've got decisions to make between two similar options. That's what we're looking at right with Jamey Eisenberg's Start 'Em & Sit 'Em column for quarterbacks. Here's who to get in and out of your lineup for Week 6. 

More Week 6 help: Start 'Em & Sit 'Em | QB | RB | WR | Starts and sits, sleepers and busts | PPR Cheat Sheet | Non-PPR Cheat Sheet | QB Preview | RB Preview | WR Preview | TE Preview | Biggest Questions | Waivers | Cut List | Trade Values | Winners and Losers | Believe It or Not

START 'EM & SIT 'EM
Quarterbacks
Start 'Em
Projections powered by Sportsline
PIT Pittsburgh • #7
Age: 38 • Experience: 17 yrs.
Weekly Breakdown
MATCHUP
vs CLE PIT -3.5 O/U 51
OPP VS QB
26th
PROJ PTS
23.6
QB RNK
9th
YTD Stats
PAYDS
1016
RUYDS
2
TD
10
INT
1
FPTS/G
18.5
Roethlisberger's comeback from last year's elbow injury has been fantastic so far, and he's scored at least 22 Fantasy points in all four games this year. He should stay hot this week against the Browns, who have allowed multiple touchdowns to opposing quarterbacks in four of five games, including two 300-yard passers.
MIA Miami • #14
Age: 37 • Experience: 16 yrs.
Weekly Breakdown
MATCHUP
vs NYJ MIA -9.5 O/U 47
OPP VS QB
19th
PROJ PTS
25
QB RNK
10th
YTD Stats
PAYDS
1344
RUYDS
131
TD
9
INT
5
FPTS/G
16.8
Philip Rivers is the only quarterback without multiple touchdowns this year against the Jets, who have also allowed two 300-yard passers. Fitzpatrick has scored at least 20 Fantasy points in four games in a row, including three games with at least 28 points. He's rolling right now, so continue to start him in all leagues.
DET Detroit • #9
Age: 32 • Experience: 12 yrs.
Weekly Breakdown
MATCHUP
@ JAC DET -3.5 O/U 54.5
OPP VS QB
27th
PROJ PTS
22.9
QB RNK
7th
YTD Stats
PAYDS
1017
RUYDS
45
TD
8
INT
3
FPTS/G
22.3
Stafford went into his Week 5 bye averaging 25.0 Fantasy points in his previous two games, and he should stay hot against the Jaguars. Every quarterback against Jacksonville this year has either multiple touchdowns or 300 passing yards, and this defense has allowed 659 yards in the past two games against Joe Burrow and Deshaun Watson.
TEN Tennessee • #17
Age: 32 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
vs HOU TEN -3 O/U 53.5
OPP VS QB
20th
PROJ PTS
23.3
QB RNK
8th
YTD Stats
PAYDS
1004
RUYDS
77
TD
10
INT
1
FPTS/G
17.7
Tannehill has scored at least 21 Fantasy points in 12 of 14 games since becoming the Titans starting quarterback in Week 7 last year, and he's scored at least 34 points in two of his past three outings. The Texans have allowed nine passing touchdowns with no interceptions this year, and Tannehill averaged 24.5 Fantasy points in two games against Houston in 2019.
TB Tampa Bay • #12
Age: 43 • Experience: 21 year
Weekly Breakdown
MATCHUP
vs GB GB -1 O/U 54.5
OPP VS QB
6th
PROJ PTS
23.1
QB RNK
11th
YTD Stats
PAYDS
1375
RUYDS
6
TD
13
INT
4
FPTS/G
21.5
It appears like Brady could have Chris Godwin (hamstring) back for this game after Godwin missed the past two outings. The last time we saw Brady with a healthy Godwin and Mike Evans for most of the game together was Week 3 at Denver, and Brady had 297 passing yards and three touchdowns. This game should be a high-scoring affair between Brady and Aaron Rodgers, and Brady also went for 369 passing yards, five touchdowns and one interception the last time he was home in Week 4 against the Chargers.
Sleepers
Projections powered by Sportsline
JAC Jacksonville • #15
Age: 24 • Experience: 2 yrs.
Weekly Breakdown
MATCHUP
vs DET DET -3.5 O/U 54.5
OPP VS QB
15th
PROJ PTS
20.7
QB RNK
12th
YTD Stats
PAYDS
1439
RUYDS
87
TD
10
INT
4
FPTS/G
18.1
Minshew might not have D.J. Chark (ankle) this week, but he should still be a low-end starting option against the Lions, who have allowed at least 240 passing yards and two touchdowns to all four opposing quarterbacks this year. And Minshew has scored at least 23 Fantasy points in four of five games in 2020.
DAL Dallas • #14
Age: 32 • Experience: 10 yrs.
Weekly Breakdown
MATCHUP
vs ARI ARI -2.5 O/U 54.5
OPP VS QB
16th
PROJ PTS
19.6
QB RNK
14th
YTD Stats
PAYDS
111
RUYDS
0
TD
0
INT
0
FPTS/G
1.2
Dalton gets his first start for the Cowboys in place of Dak Prescott (ankle), and it's a favorable matchup against the Cardinals at home, especially with Chandler Jones (biceps) now out. Three of five quarterbacks against the Cardinals have at least 259 passing yards and two touchdowns this year, and the two who failed to accomplish that were Dwayne Haskins and Joe Flacco.
MIN Minnesota • #8
Age: 32 • Experience: 9 yrs.
Weekly Breakdown
MATCHUP
vs ATL MIN -3.5 O/U 55
OPP VS QB
32nd
PROJ PTS
21.4
QB RNK
17th
YTD Stats
PAYDS
1132
RUYDS
55
TD
8
INT
7
FPTS/G
13.3
The Falcons defense has been so bad against opposing quarterbacks that Teddy Bridgewater's 313 passing yards and two touchdowns last week was the worst performance against Atlanta this year. Cousins might not have a huge game given his typical low volume of passes, but he should be a decent streamer in deeper leagues. And Cousins does have multiple touchdowns in two of his past three games.
Sit 'Em
Projections powered by Sportsline
PHI Philadelphia • #11
Age: 27 • Experience: 5 yrs.
Weekly Breakdown
MATCHUP
vs BAL BAL -7.5 O/U 47.5
OPP VS QB
12th
PROJ PTS
14.4
QB RNK
19th
YTD Stats
PAYDS
1188
RUYDS
122
TD
9
INT
9
FPTS/G
15.2
Despite some tough matchups the past two games against San Francisco and Pittsburgh on the road, Wentz has scored at least 21 Fantasy points in each outing. And he also had 23 Fantasy points against Cincinnati in Week 3, so he's been a low-end starter for three weeks in a row. Still, I would avoid him against Baltimore at home, and the only quarterback with multiple touchdowns against the Ravens this year was Patrick Mahomes in Week 3.
CIN Cincinnati • #9
Age: 23 • Experience: Rookie
Weekly Breakdown
MATCHUP
@ IND IND -7.5 O/U 46.5
OPP VS QB
1st
PROJ PTS
17.5
QB RNK
20th
YTD Stats
PAYDS
1304
RUYDS
85
TD
7
INT
3
FPTS/G
17.7
Burrow comes into Week 6 against the Colts with a combined 21 Fantasy points in his past two games against Jacksonville and Baltimore, and he should struggle again this week. The Colts are No. 2 in fewest Fantasy points allowed to opposing quarterbacks, and they are the only team in the NFL with more interceptions (nine) than passing touchdowns allowed (seven).
CLE Cleveland • #6
Age: 25 • Experience: 3 yrs.
Weekly Breakdown
MATCHUP
@ PIT PIT -3.5 O/U 51
OPP VS QB
4th
PROJ PTS
13.8
QB RNK
22nd
YTD Stats
PAYDS
976
RUYDS
32
TD
9
INT
4
FPTS/G
13.7
Mayfield has scored exactly 18 Fantasy points in four games in a row, and he has yet to score more than that in any game this season. In three career games against the Steelers, Mayfield has averaged 17.0 Fantasy points per game, including 26 total points in two outings at Pittsburgh. He's also dealing with a rib injury coming into this game, which could hinder his performance.
SF San Francisco • #10
Age: 28 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs LAR LAR -3.5 O/U 51
OPP VS QB
9th
PROJ PTS
6.9
QB RNK
23rd
YTD Stats
PAYDS
467
RUYDS
9
TD
4
INT
2
FPTS/G
13.5
Garoppolo is expected to play this week despite leaving Week 5 against Miami with his lingering ankle injury. As a result, I'd be hesitant to use Garoppolo even in two-quarterback and Superflex leagues. It's also a tough matchup against the Rams, who have allowed just Josh Allen in Week 3 to score multiple touchdowns against them this year.
Bust Alert
Projections powered by Sportsline
CAR Carolina • #5
Age: 27 • Experience: 7 yrs.
Weekly Breakdown
MATCHUP
vs CHI CAR -1.5 O/U 44.5
OPP VS QB
2nd
PROJ PTS
16.9
QB RNK
15th
YTD Stats
PAYDS
1460
RUYDS
73
TD
7
INT
3
FPTS/G
15.3
It's a credit to Bridgewater that he's landed in this spot, which is typically reserved for must-start players who could struggle. In the past two games, Bridgewater has been great with at least 24 Fantasy points against Arizona and Atlanta, and he's scored at least 20 Fantasy points in three of five games this year. But he should regress in this matchup against the Bears, who have allowed just four passing touchdowns on the season, including matchups with Stafford, Ryan and Brady. It's impressive the way Bridgewater has played in 2020, but he's not matchup proof yet as a Fantasy option.

So who should you start and sit this week? And which surprising quarterback could lead you to victory? Visit SportsLine now to get Week 6 rankings for every position, plus see which QB is going to come out of nowhere to crack the top 10, all from the model that out-performed experts big-time last season.