The Lions placed Anzalone (shoulder) on injured reserve Monday.
Anzalone's move to IR comes just hours after Chris Burke of The Athletic reported that the linebacker suffered a season-ending injury in Sunday's win over the Cardinals. Fortunately for Anzalone, he's not expected to face a long-term recovery period, which suggests he'll avoid surgery. The 27-year-old wraps up his first season in Detroit with 78 tackles and an interception over 14 games.