Barnes exited Sunday's game against the Cardinals with a knee injury and is questionable to return, Eric Woodyard of ESPN.com reports.
Barnes had to be carted to the locker room in the second quarter. Prior to leaving, Barnes recorded one tackle (one solo). Starting LB Alex Anzalone (concussion) is already inactive for Week 3. Ben Niemann and Jalen Reeves-Maybin will be next up for snaps at linebacker for Detroit.