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The Titans and Bills have created iconic moments together, ranging from "The Comeback" to the "Music City Miracle." Another moment was created last year, when Derrick Henry stiff-armed Josh Norman into a meme. The two teams will have a chance on Monday Night Football to create more memories as the Titans host the Bills. Henry is the league's leading rusher heading into Week 6 and may be the first name that comes to mind when filling out your NFL DFS lineups.

The reigning Offensive Player of the Year has some competition when it comes to top billing for Titans vs. Bills. Josh Allen is putting up MVP-worthy numbers and has been one of the best NFL DFS picks all season. Allen and Henry are just two names in Bills vs. Titans DFS lineups to consider, and you'll have to scour the rest of the NFL DFS player pool to fill out your picks. Before locking in any NFL DFS picks for Titans vs. Bills, be sure to check out the NFL DFS advice, player rankings, stacks and top daily Fantasy football picks from SportsLine's Mike McClure

McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

Now, McClure has turned his attention to the Titans vs. Bills NFL DFS slate and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.

Top NFL DFS picks for Bills vs. Titans 

One of McClure's top NFL DFS picks for Monday Night Football is Titans quarterback Ryan Tannehill. The former Dolphins' QB had one of the best games of his career last year against the Bills. Tannehill threw for 195 yards and three touchdowns while also rushing for 42 yards and a score. It's one of two games in his career he's passed for at least three touchdowns, rushed for at least one touchdown and didn't commit a turnover.

The Bills' defense may have improved, but it's still susceptible to mobile quarterbacks. Patrick Mahomes rushed for a career-high 61 yards last week against Buffalo, while Taylor Heinicke scored a TD on the ground against the Bills in Week 3. Tannehill also has a major weapon this time around that he didn't have last year, Julio Jones, who returned to practice this week and is expected to play.

Part of McClure's optimal NFL DFS strategy also includes rostering Bills tight end Dawson Knox, who is coming off a career-high of 117 receiving yards in Week 5. Knox had multiple receptions of 40-plus yards and easily surpassed his previous career-high of 67 yards. He also scored last week which was fifth touchdown over the last four games.

Knox has become Allen's top red-zone target as indicated by his four targets inside the 10-yard line which even outpaces All-Pro WR Stefon Diggs. Knox gets a great matchup on Monday Night Football vs. a Titans team that struggled against opposing tight ends last week. Tennessee allowed converted receiver Dan Arnold to post six grabs for 64 yards while journeyman TE Jacob Hollister caught a TD pass. Knox should have more opportunities than both of those players and makes for one of Monday's top NFL DFS picks.

How to set NFL DFS lineups for Titans vs. Bills

McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday night. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here

So who is Mike McClure putting in his optimal NFL DFS lineups for Monday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2M in winnings, and find out.