Ioannidis (calf) has been ruled out for Sunday's game against the Broncos.
Ioannidis missed last Sunday's loss to the Ravens due to a calf issue he sustained Week 10 versus the Falcons, and he'll again watch from the sidelines this weekend with the same injury. In his absence, Derrick Brown, Bravvion Roy and Marquan McCall are in line to serve as Carolina's top defensive-tackle options.