Henderson suffered a high-ankle sprain in Sunday's 20-9 loss to the Seahawks and is expected to be placed on injured reserve, Eric D. Williams of SI.com reports.

Henderson logged 62 yards on 12 carries before exiting Sunday's loss. He now will miss the team's regular-season finale against the Cardinals, and it remains to be seen if he will be available for a potential postseason berth. Cam Akers (ankle) still could be available against Arizona, but if he isn't look for Malcolm Brown to see the majority of the work out of the backfield.

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