Simmons (hamstring) has been ruled out ahead of Sunday's matchup against the Chargers, Jim Wyatt of the Titans' official site reports.
The 2019 first-round pick from Mississippi State is now in line to miss his second consecutive game due to a hamstring injury sustained in the Week 7 loss to the Patriots. While Simmons remains sidelined Sunday, expect C.J. Ravenell to have an expanded role on Tennessee's defensive line.