McNichols was listed as a non-participant on Wednesday's estimated practice report due to a rib injury, John Glennon of The Athletic reports.
McNichols didn't show any signs of injury during Tuesday's win over the Bills; in fact, he saw ample use during Tennessee's final drive, carrying four times for eight yards. If McNichols is able to shake off this injury before Sunday's game against the Texans arrives, he could handle the change-of-pace role behind starter Derrick Henry. The Titans' normal No. 2 back, Darrynton Evans, (hamstring) was also listed as a non-participant Wednesday and may have a tough time gaining clearance for the Week 6 game.