No Fantasy season is ever over after two weeks, but if you drafted Jamaal Charles in Round 1, A.J. Green in Round 2 and spent picks on Ryan Mathews, DeSean Jackson, Knowshon Moreno and Robert Griffin III throughout the rest of your draft ... yeah. Not your week.

All of those players left with injuries in Week 2, making it the roughest week we've seen in a while in terms of difference-makers falling out of Fantasy lineups. But none is bigger than Charles' injury.

Charles took a handoff in the first quarter of the Chiefs' game against the Broncos, ran into a pile and seemingly got rolled up upon by a teammate. He was able to limp off under his own power, got his left ankle checked out on the sideline by trainers and later walked from the sideline to the locker room but didn't return. After the game, Andy Reid said he had a sprained ankle and didn't comment further. Charles has totaled 46 yards on 14 carries through two games and has more injuries than touchdowns.

Meanwhile, his replacement, Knile Davis, cut through the Broncos like a hot sharp object through a smooth dairy-based substance. Davis scored twice and had 79 rush yards on 22 carries and 26 receiving yards on six catches with a pair of rushing touchdowns. It goes without question that if Charles misses time with the ankle that Davis will step in as the primary rusher for the Chiefs. He's currently owned in 35 percent of CBSSports.com leagues, mostly by those who spent a first-round pick on Charles. Expect him to be the hottest name off waivers this coming week.

The next-best pickup off waivers figures to be Donald Brown, who will replace Mathews for however long the Chargers are without his services (it might not be too long). Mathews couldn't grasp a fourth-quarter handoff from Philip Rivers and seemingly got rolled up on in the scrum on the field. It wrapped up what was otherwise a bad game for Mathews as he had 31 yards on 11 carries and 26 yards on two catches against a very good Seahawks defense. Brown is owned in 18 percent of CBSSports.com leagues.

Knowshon Moreno suffered a dislocated elbow very early on in Sunday's game at the Bills according to ProFootballTalk.com and will miss at least four weeks (and maybe eight weeks). Lamar Miller is the well-owned back (89 percent of leagues) who is expected to replace Moreno, even though he himself suffered an ankle injury late in the game. There doesn't seem to be too much concern for Miller's status as of Sunday night, but if he's dinged we'll see undrafted rookie Damien Williams take over in the backfield for Miami.

And finally, there's Robert Griffin III, who suffered a dislocated ankle and figures to be out for the year. Kirk Cousins took his place and put together a great outing against a bad Jaguars defense, but he's got the look and reputation of being nothing more than a bye-week quarterback choice off waivers, not a sleeper.

However, it's worth noting that the Week 4 byes are coming and several high-profile Fantasy quarterbacks will go missing. Cousins will have a home game against the Giants in Week 4 and could be effective. It's not crazy to think an owner could add Cousins off waivers now and then trade him to a desperate owner in Week 4. And that's if Cousins doesn't first instill more confidence in Week 3 at Philadelphia.

Let's look at the rest of the good and the bad from Week 2.

Quarterbacks

Player on the rise

You can't not be on the rise if you attack the Seahawks vaunted secondary with the one position they've more or less locked down for the past year-plus. But that's what Philip Rivers did in Week 2, torching the Seahawks for 284 yards and three touchdowns -- all to Antonio Gates.

It was a gutsy performance that only 21 percent of CBSSports.com owners could truly appreciate because those are the ones who looked past the matchup and started Rivers. They're just as brave as Rivers. The best news? The Chargers next five games are at Buffalo, vs. Jacksonville, vs. the Jets, at Oakland and vs. Kansas City. Rivers might finish in the Top 10 in each of those games, especially if the Chargers don't have Ryan Mathews to help balance the offense.

Player on the decline

It's strike two for Tony Romo, though this week it's not because of what he did. It's what his running back did.

The Cowboys got out to a nice lead on the Titans on the wheels of DeMarco Murray and decided not to tempt fate and give Romo a heavy amount of work. It led to a win. The Cowboys play at St. Louis in Week 3 and could conceivably use the same sort of safe game plan, which in turn would mean a third straight week of disappointment for Romo owners. Things will change and the Cowboys will be in some battles where they'll need Romo to throw.

It'll be interesting to see how many Fantasy owners are willing to stick with him by then.

Quarterback injuries: Robert Griffin III (dislocated ankle), Carson Palmer (shoulder; was inactive)

Quarterback waivers: Joe Flacco (61 percent ownership), Eli Manning (49 percent), Josh McCown (36 percent), Geno Smith (18 percent), Blake Bortles (15 percent), Teddy Bridgewater (13 percent), Kirk Cousins (8 percent).

Of note: Tom Brady (11 Fantasy points) had another weak game statistically but did all that was asked of him in a blowout win over the Vikings where the New England defense made it easy for the offense. It could happen again next week when the lowly Raiders come to Foxboro. ... Russell Wilson has posted back-to-back 20-point outings (21 points at San Diego) and continues to morph into a regular starting choice. He'll probably be considered a Top 12 option for his Super Bowl rematch against the Broncos in Week 3. ... Cam Newton also made a nice return to Fantasy lineups (20 Fantasy points). Though his offensive line did him no favors and forced him to move around in the pocket, he acquitted himself well enough for his first game of the season. A late-game ankle tweak is something to watch, but he should be considered a good option for Week 3 against a beleaguered Steelers defense. ... We're getting closer to seeing Blake Bortles and Teddy Bridgewater for the Jaguars and Vikings, respectively.

Running backs

Players on the rise

Leave it to a game between the Saints and Browns to spawn two running backs who could end up being considered must-start options for the foreseeable future.

For the second straight week, Mark Ingram didn't get a lot of carries but did cash in for a touchdown and tally a healthy amount of yardage. He benefits greatly from being the best running back in the Saints rotation, and with the way defenses play against them, he'll almost never see more than six in the box. The matchup against the Vikings in Week 3 is gorgeous, but news of a hand injury on Monday could put a halt to his hot start.

As for the Browns run game, Terrance West totaled 90 yards and scored to help pace his team and keep them in the ball game on Sunday. West is a fine do-it-all back who looks solid in the Browns' rushing scheme. There's a real chance he ends up continuing on as Cleveland's starter even when Ben Tate comes back from injury. It'll be a real test for West against the Ravens run defense in Week 3.

Player on the decline

A lot of Fantasy owners, myself included, took the bait on Toby Gerhart. We were blinded by the promise of tons of touches in a progressive offense. And we knew that Gerhart wasn't fast but could do everything else well.

Unfortunately through two weeks, he's been buried behind his offensive line and has 25 carries for 50 yards, four catches for 24 yards and not even a hint of a touchdown. Somewhere, BenJarvus Green-Ellis is laughing. Forget about the investment made in Gerhart on Draft Day and find a nice spot on your bench for him until further notice. You might even be able to get away with cutting him in leagues with 10 owners or less.

Running back injuries: Jamaal Charles (sprained ankle), Ryan Mathews (knee), Knowshon Moreno (elbow), Roy Helu (quad), Doug Martin (leg; was inactive)

Running back waivers: Justin Forsett (76 percent), Chris Ivory (76 percent), Jeremy Hill (68 percent), Darren McFadden (65 percent), Matt Asiata (48 percent), Isaiah Crowell (40 percent), Bobby Rainey (43 percent), Knile Davis (36 percent), Jonathan Stewart (30 percent), Jerick McKinnon (22 percent), Donald Brown (18 percent), Jonathan Dwyer (17 percent), Damien Williams (0 percent)

Of note: Giovani Bernard finished Sunday as the top running back in Fantasy with 22 points, but teammate Jeremy Hill wasn't too far behind with 15 points. That's just as much a testament to the Bengals run game as it is the sad, sad Falcons run defense. The Bucs with Bobby Rainey (who had 17 Fantasy points himself) are up next. Rainey is a borderline must-start if Doug Martin remains sidelined. ... Stevan Ridley was given the majority of the work for the Patriots, getting more touches than Tom Brady had pass attempts. That wasn't by design -- that was from the flow of the game. It could happen again next week against the Raiders, so have some confidence in Ridley. ... Darren McFadden had a crummy rushing average but found the end zone to finish with his first double-digit Fantasy game since Week 8 of last season.

Wide receivers

Player on the rise

Welcome to the NFL, Sammy Watkins.

Despite the handicap of catching passes from the hot-and-cold EJ Manuel, Watkins found the end zone and nearly had a second touchdown if not for an errant pass. He also turned 11 targets into eight catches for 117 yards with the score, using his darting speed and physical nature to help him separate from Miami's coverage. He was only started in 10 percent of leagues but will get a shot from many owners over the next three weeks when he plays against the Chargers, Texans and Lions.

Players on the decline

A lot of people believed Buccaneers receiver Vincent Jackson would emulate Brandon Marshall or Alshon Jeffery and be an easy downfield target for Josh McCown to heave it to. But through a pair of games, he has eight catches for 87 yards with nothing in the way of touchdowns. Worse yet, his longest catch thus far has counted for 20 yards and his fellow big-man receiver, Mike Evans, hobbled off late against the Rams on Sunday.

While he'll play at Atlanta in Week 3, the game is on Thursday night and receivers tend to struggle on short weeks. He'll follow that up with two more road games at Pittsburgh and New Orleans.

Owners might just opt to stick with him and wait for the "boom" weeks, but McCown is not faring so well behind a messy offensive line and there's no promise that V-Jack will get his numbers.

Wide receiver injuries: A.J. Green (foot), DeSean Jackson (sprained shoulder), Eric Decker (hamstring), Mike Evans (undisclosed), Allen Hurns (left ankle), Tavon Austin (knee)

Wide receiver waivers: DeAndre Hopkins (76 percent), Rueben Randle (69 percent), Greg Jennings (59 percent), Andrew Hawkins (46 percent), James Jones (36 percent), Brian Quick (21 percent), Miles Austin (19 percent), Mohamed Sanu (14 percent), Allen Robinson (2 percent), Jason Avant (1 percent)

Of note: Mike Wallace delivered a nice stat line for the second straight week (11 Fantasy points) and even made a heck of a one-armed touchdown catch in close coverage by Bills corner Stephon Gilmore. Last year he had back-to-back big games just once. He'll have a chance for a third-straight nice game in Week 3 against the Chiefs. ... DeAndre Hopkins scored for the second week in a row but didn't get 10-plus Fantasy points in the process. He has two touchdowns, J.J. Watt has one receiving touchdown and Andre Johnson has none. ... Brian Quick has emerged as the Rams' best receiver and is a must-own in PPR leagues. Ditto that for Andrew Hawkins with the Browns.

Tight ends

Player on the rise

We can't ignore Delanie Walker anymore.

Through two weeks, he has 13 catches for 179 yards and two touchdowns, numbers that dwarf the production of pretty much anyone at the position save for Jimmy Graham, Julius Thomas and Antonio Gates. He was the apple of Jake Locker's eye in Week 2 and came through with a red zone touchdown in Week 1. The tide might turn in Week 3 against the Bengals, who could pick up on Walker and leave their corners to work one-on-one against the Titans receivers, but in Week 4 at Indianapolis and Week 5 against the Browns, we could see Walker step up and be a great Fantasy starter.

Player on the decline

Heath Miller is off to a brutal start for the Steelers, snagging seven catches for 61 yards and a fumble lost. This was supposed to be the season he'd bounce back and put up numbers close to what he had in 2012, but for now it looks like Miller is slowing down (8.7 yards per catch). Perhaps the catches that Le'Veon Bell is getting is taking away from Miller.

The Steelers will play at Carolina in Week 3, a matchup they'll have to throw the ball in, but Miller is an easy cover everywhere on the field including the end zone and could come away from the game with another light stat line. Be careful using him.

Tight end injuries: Marcedes Lewis (ankle)

Tight end waivers: Delanie Walker (73 percent), Travis Kelce (44 percent), Larry Donnell (33 percent), Niles Paul (9 percent), Owen Daniels (4 percent)

Of note: Antonio Gates is a beast. Anytime you can score one touchdown on the Seahawks you're doing something right. Score three?! That's amazing. And like his pal Philip Rivers, Gates has nothing but beautiful matchups on the horizon. Too bad you can't trade for him on the cheap like you might be able to do with his teammate Keenan Allen. ... Niles Paul continued to show off for the Redskins and could become a welcome addition in Fantasy after two nice weeks to begin the season. We'd bank on another high-reception outing at Philadelphia in Week 3. It might even help him to have Kirk Cousins under center. ... Travis Kelce played more for the Chiefs and ended up as their top receiving threat at Denver, catching four passes for 81 yards. This could be the beginning for him. The Chiefs play the Dolphins in Miami in Week 3.