MacKinnon had four shots on net over a forward-high 19:24 of ice time in Wednesday's 4-1 loss to St. Louis.
MacKinnon was silenced by goalie Jordan Binnington and not on the ice for the Avalanche's lone goal, a power play tally by Andre Burakovsky. MacKinnon and the Avalanche will look to shake off the loss when the teams meet again in Denver on Friday.
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