The 2021 Open Championship will begin at 1:35 a.m. ET on Thursday at Royal St. George's Golf Club on the southeast coast of England. The par-70 venue plays out to nearly 7,200 yards and this is the 15th time that the 134-year-old club has hosted the British Open. Weather is expected to be relatively docile by Open standards, with temperatures expected in the high-60s and low-70s without much chance of precipitation and wind expected to blow steadily between 10 and 20 mph.

Jon Rahm is the 7-1 favorite in the 2021 Open Championship odds from William Hill Sportsbook, while Bryson DeChambeau is 14-1 and Dustin Johnson is 15-1. Shane Lowry is the defending champion and listed at 33-1 in the Open Championship odds 2021, while past champions like Louis Oosthuizen (30-1), Phil Mickelson (70-1) and Francesco Molinari (100-1) are all long shots as well. Before locking in your 2021 Open Championship picks, be sure to see the latest golf predictions and projected leaderboard from the proven computer model at SportsLine.

SportsLine's proprietary model, built by DFS pro Mike McClure, has been red-hot since the PGA Tour resumed last June. In fact, it's up over $8,000 on its best bets since the restart, nailing tournament after tournament.

At the 2021 U.S. Open, McClure's model was all over Jon Rahm's first career major championship victory at 10-1 from the start. Rahm was two strokes off the lead heading into the weekend, but the model still projected him as the winner at that point. The result: Rahm birdied the 17th and 18th holes in dramatic fashion to send his backers straight to the pay window. At the 2021 Masters, McClure nailed Rahm's (+250) top-five finish in his best bets, as well as Corey Conners' (+550) top-10 showing. McClure's best bets netted over $450 at the Masters.

In addition, McClure was all over Daniel Berger's win at +1400 in his best bets at the AT&T Pebble Beach Pro-Am in February. McClure also nailed Viktor Hovland's (+2500) victory in the Mayakoba Golf Classic in December. That was one of many huge calls he's made in the past several months.

This same model has also nailed a whopping seven majors entering the weekend. Anyone who has followed it has seen massive returns.

Now that the 2021 Open Championship field is set, SportsLine simulated the event 10,000 times, and the results were surprising. Head to SportsLine now to see the projected 2021 Open Championship leaderboard.

The model's top 2021 Open Championship predictions 

One huge shocker the model is calling for at the Open Championship 2021: Brooks Koepka, a four-time major champion and one of the top favorites, struggles mightily doesn't even crack the top 10. Koepka saves his best golf for major championships, and he's finished seventh or better in three of his last four major starts. However, Koepka has finished 39th or worse in three of his last six starts at the Open Championship and ranks 165th in driving accuracy percentage (55.84), which could spell trouble at Royal St George's Golf Club.

On the other hand, the model has taken into account that Jordan Spieth was the last American to win the Open Championship, as he won by three shots over Matt Kuchar in the 2017 Open at Royal Birkdale. Times got tough for Spieth following the win, as he went nearly four years without another victory. However, the model knows he's been playing much better golf of late. He's finished in the top 10 eight times in his last 13 starts and ended the winless drought with a victory at the 2021 Valero Texas Open. Spieth finished third at the 2021 Masters to prove that he was back in a position to contend for majors.

The proven model also is factoring in that Justin Thomas has all the tools needed to win the Claret Jug. Thomas will enter the Open Championship 2021 confident he can secure his second major title. He finished 11th at the Open in 2019 and secured a top-10 finish last week at the Scottish Open. Thomas' uncanny ability to shape his iron shots will go a long way this week at Royal St. George's. The 28-year-old currently ranks fifth on tour in strokes gained approaching the green (.853) and 10th in total strokes gained (1.503). He's also been sensational with his putter this season, ranking fourth in putting average (1.715) and sixth in one-putt percentage (42.97).

How to make 2021 Open Championship picks

Among the options the model is touting is a long shot who comes in at well over 35-1 Open Championship odds 2021. Pure ball-strikers who can putt well excel at the Open, and this player fits the bill. Anyone who backs this underdog could cash in huge. You can only see who it is here.

So who will win the Open Championship 2021? And which long shot stuns the golfing world? Check out the odds below and then visit SportsLine to see the projected 2021 Open Championship leaderboard, all from the model that's nailed seven golf majors, including Rahm's epic U.S. Open victory.

2021 Open Championship odds

Jon Rahm 7-1
Bryson DeChambeau 14-1
Dustin Johnson 15-1
Rory McIlroy 16-1
Xander Schauffele 16-1
Brooks Koepka 16-1
Justin Thomas 20-1
Jordan Spieth 20-1
Louis Oosthuizen 30-1
Shane Lowry 33-1
Tommy Fleetwood 33-1
Patrick Cantlay 33-1
Matthew Fitzpatrick 33-1
Patrick Reed 33-1
Tyrrell Hatton 33-1
Paul Casey 35-1
Lee Westwood 35-1
Viktor Hovland 40-1
Scottie Scheffler 40-1
Webb Simpson 40-1
Collin Morikawa 40-1
Tony Finau 45-1
Justin Rose 45-1
Daniel Berger 50-1
Cameron Smith 55-1
Sergio Garcia 55-1
Marc Leishman 55-1
Branden Grace 55-1
Joaquin Niemann 60-1
Ian Poulter 60-1
Christiaan Bezuidenhout 66-1
Adam Scott 66-1
Abraham Ancer 66-1
Garrick Higgo 66-1
Will Zalatoris 66-1
Rickie Fowler 66-1
Robert MacIntyre 66-1
Lucas Herbert 70-1
Phil Mickelson 70-1
Harris English 70-1
Jason Day 70-1
Ryan Palmer 90-1
Jason Kokrak 90-1
Sam Burns 100-1
Alex Noren 100-1
Corey Conners 100-1
Thomas Detry 100-1
Matt Wallace 100-1
Francesco Molinari 100-1
Martin Kaymer 100-1
Brian Harman 125-1
Victor Perez 125-1
Guido Migliozzi 125-1
Danny Willett 125-1
Min Woo Lee 125-1
Stewart Cink 125-1
Max Homa 125-1
Gary Woodland 125-1
Bernd Wiesberger 125-1
Russell Henley 125-1
Padraig Harrington 125-1
Billy Horschel 150-1
Matt Kuchar 150-1
Charley Hoffman 150-1
Harold Varner 150-1
Keegan Bradley 150-1
Kevin Streelman 150-1
Kevin Kisner 150-1
Richard Bland 150-1
Andy Sullivan 175-1
Emiliano Grillo 200-1
Jason Scrivener 200-1
Brendon Todd 200-1
Carlos Ortiz 200-1
Rafa Cabrera Bello 200-1
Lucas Glover 200-1
Henrik Stenson 200-1
Cameron Tringale 200-1
Sebastian Munoz 200-1
Antoine Rozner 200-1
Erik Van Rooyen 200-1
Matt Jones 200-1
John Catlin 200-1
Chez Reavie 250-1
Aaron Rai 250-1
Matthias Schwab 250-1
Troy Merritt 250-1
Johannes Veerman 250-1
Brandt Snedeker 250-1
Dean Burmester 250-1
Joel Dahmen 250-1
Ryan Fox 250-1
Dylan Frittelli 250-1
Justin Harding 250-1
Chris Kirk 250-1
Mackenzie Hughes 300-1
Kurt Kitayama 300-1
Brendan Steele 300-1
Takumi Kanaya 300-1
Adam Hadwin 300-1
Lanto Griffin 300-1
Joost Luiten 300-1
Talor Gooch 300-1
Jack Senior 300-1
Romain Langasque 300-1
C.T. Pan 350-1
Jazz Janewattananond 350-1
Marcus Armitage 350-1
Mike Lorenzo-Vera 400-1
Marcel Siem 400-1
Daniel Van Tonder 400-1
Jimmy Walker 400-1
Rikard Karlberg 400-1
Paul Waring 400-1
Benjamin Hebert 400-1
Jorge Campillo 400-1
Keith Mitchell 400-1
Shaun Norris 400-1
Adam Long 400-1
Hao-Tong Li 400-1
Rikuya Hoshino 400-1
Byeong-Hun An 400-1
Marcus Kinhult 400-1
Chan Kim 500-1
Gonzalo Fernandez-Castano 500-1
Marcel Schneider 500-1
Richard Mansell 500-1
Yuki Inamori 500-1
J.C. Ritchie 500-1
Ernie Els 500-1
Cole Hammer 500-1
Darren Clarke 500-1
Yuxin Lin 500-1
Ryosuke Kinoshita 500-1
Matthias Schmid 500-1
Daniel Hillier 750-1
Brad Kennedy 750-1
Ryutaro Nagano 750-1
Poom Saksansin 750-1
Jaco Ahlers 750-1
Christoffer Bring 1000-1
Richard T. Lee 1000-1
Nicholas Poppleton 1000-1
Deyen Lawson 1000-1
Jonathan Thomson 1000-1
Sam Bairstow 1000-1
Aaron Pike 1000-1
Laird Shepherd 1000-1
Ben Hutchinson 1000-1
Joe Long 1500-1
Sam Forgan 1500-1
Ricardo Celia 1500-1
Abel Gallegos 1500-1
Daniel Croft 2000-1
Connor Wordsdall 2000-1
Todd Hamilton 2000-1