Cruz added two doubles and drove in seven runs for the reigning AL Central champion Twins, who won two of three. Maeda (1-0), a Japanese right-hander who was traded in February from the Los Angeles Dodgers, allowed two runs and struck out six in five innings.
Highly touted rookie Luis Robert hit his first career home run and right-hander Reynaldo López (0-1) and left fielder Eloy Jiménez exited early with injuries for the White Sox.
Cave hit his second career grand slam in the first. Jiménez crashed into the fence chasing the ball and left the following inning because he was light headed.
Cruz hit a three-run double before Eddie Rosario doubled and Luis Arraez singled to extend the Twins' lead to 9-0 in the second inning.
Cruz smacked a 435-foot solo shot in the fourth and added a three-run drive in the eighth for his 35th career multi-homer game. He went 7 for 13 with 10 RBIs and three home runs in the series.
Marwin Gonzalez added a solo shot in the ninth for the Twins, who hit a major league-record 307 homers last season.
Robert hit a first-pitch, two-run homer off Maeda to cut the Twins' lead to 10-2 in the fifth.
López exited with right shoulder tightness after recording just two outs, throwing 38 pitches and allowing four runs. Lopez was 0-3 with a 9.60 ERA in three starts against the Twins last season.
Twins: C Willians Astudillo (COVID-19) has been cleared to join the St. Paul group after testing negative. No timeline is set for his return to the 30-man roster. He missed all of summer camp after testing positive for the virus. …RHP Jake Odorizzi (sore back) will throw a bullpen session early this week, manager Rocky Baldelli said. …CF Byron Buxton (sprained left foot) could return Tuesday in the home opener against St. Louis. …LHP Lewis Thorpe exited after a grounder hit his leg in the eighth.
White Sox: INF Yoán Moncada, who missed the start of summer camp due to COVID-19, got Sunday off for rest but is expected to play all three games in Cleveland, manager Rick Renteria said. …OF Nomar Mazara, who went on the 10-day IL Wednesday for an undisclosed reason, is "progressing well," Renteria said.
Twins: RHP Homer Bailey makes his Minnesota debut in Tuesday's home opener against St. Louis and RHP Carlos Martinez. Bailey went 13-9 with a 4.57 ERA with Kansas City and Oakland last season.
White Sox: RHP Dylan Cease, who was 4-7 with a 5.79 ERA last season, starts at Cleveland to open a three-game series Monday. RHP Aaron Civale pitches for the Indians.
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