A day after picking off David Fletcher at third base to end a 3-2 win, Perez drove in two runs. The All-Star catcher went 8 for 12 with four RBIs this week against Los Angeles.
''This game is about making adjustments and that's why we are in the big leagues,'' Perez said. ''I just try to get better and help my team win.''
Carlos Santana also homered as the Royals took two of three from the Angels. It was the Royals' second series win of the year - it took them 14 tries to do that during the pandemic-shortened season.
Keller (1-1) went 5 2/3 innings and gave up one run and four hits, striking out five and walking one. That was a major step forward after he allowing 10 earned runs in 4 2/3 innings in his first two starts.
''That was nice to have this outing,'' he said. ''I just needed to get back to who I was and felt good today. I think being able to fix my mechanical stuff but also just competing and having the right mentality.''
The Royals bullpen of Jake Brentz, Josh Staumont, and Tyler Zuber pitched 3 1/3 scoreless innings, giving up two hits.
Griffin Canning (0-1) went five innings and permitted two runs and six hits.
''We had opportunities, but overall our pitching was pretty good,'' Angels manager Joe Maddon said. ''We just needed to score more runs.''
Perez hit his third homer of the season, a solo drive in the third. Perez doubled home Whit Merrifield in the seventh.
''He was huge for us today,'' Royals manager Mike Matheny said. ''This guy just continues to amaze us with how good he is.''
Jared Walsh doubled home Mike Trout in the fifth, pulling the Angels within 2-1.
Angels: OF Justin Upton was scratched on Tuesday night and remained out of the lineup on Wednesday with back stiffness.
Royals: Reinstated RHP Josh Staumont off the injured list and optioned RHP Carlos Hernandez. OF Nick Heath was designated for assignment.
Angels: Return home to take on Minnesota on Friday with Andrew Heaney on the mound (1-1, 7.00).
Royals: Continue their homestand with a four-game set that starts on Thursday with Jakob Junis (0-0, 0.00) starting against Toronto.
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