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The San Diego Padres worked hard over the winter to upgrade their starting rotation, and the moves have paid off already in the 2021 MLB season. Joe Musgrove, Yu Darvish and Blake Snell have combined to post a 3-0 record and 1.70 ERA, while Musgrove also produced the first no-hitter in franchise history. Should you expect Snell to come up with another strong start for the Padres on Tuesday, or is there value in the Pittsburgh Pirates hitting him hard and bringing a large return on the money line?

The latest MLB odds for Tuesday from William Hill Sportsbook list the Padres at -240 (risk $240 to win $100) against the Pirates. Other MLB lines of note include the Milwaukee Brewers at -140 against the Chicago Cubs and the San Francisco Giants as slim money-line favorites (-111) versus the Cincinnati Reds. Before making any MLB picks on those games or others, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 15-7 on all top-rated MLB picks through two weeks, returning over $500. Anyone following it has seen huge rewards.

Now, the model has crunched the number for Tuesday MLB schedule and posted its best bets. Parlaying these five MLB picks will pay more than 27-1. Head to SportsLine to see the picks

Top MLB picks for Tuesday, April 13

One of the MLB picks the model loves for Tuesday: The Kansas City Royals pick up the win at +125 on the money line against the Los Angeles Angels. Kansas City was unable to control Los Angeles' offense in Monday's season opener, as Mike Trout homered and Shohei Ohtani went 3-for-5 with three RBIs in the Angels' 10-3 victory. The Royals surrendered 14 hits in the setback but are likely to have a better showing with Danny Duffy on the mound. The 32-year-old left-hander was superb in his season debut at Cleveland, limiting the Indians to only two hits in six scoreless innings.

Duffy settled for a no-decision in that outing, which marked the third time in four starts dating back to last season that he gave up fewer than two runs. Kansas City is hoping Salvador Perez can continue to swing the bat well after his performance on Monday. The 30-year-old catcher went 4-for-4 with an RBI in the series opener after entering the contest just 5-for-27 on the season.

How to make MLB predictions, parlays for Tuesday, April 13

The model has locked in four other MLB best bets, including multiple underdog plays that would lead to huge returns. You can see best bets only at SportsLine.

So which MLB picks should you make on Tuesday for a shot at a mammoth return of over 27-1? And which underdogs do you need to be all over? Visit SportsLine now to see Tuesday MLB picks, all from the projection model that returned more than $1,400 to $100 bettors during the 2019 season, and find out.