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The Los Angeles Dodgers and San Diego Padres resume their seasonlong struggle for supremacy in the NL West -- and possibly the entire NL -- when the West Coast rivals open a four-game series on Thursday at Dodger Stadium in Los Angeles. The reigning World Series champion Dodgers (14-4) own the best record in baseball. Meanwhile the Padres (10-10) announced themselves as legitimate contenders for the title after a series of acquisitions in the offseason. First pitch is 10:10 p.m. ET. Los Angeles is the -172 money-line favorite (risk $172 to win $100) in the latest Dodgers vs. Padres odds at William Hill Sportsbook, while the over-under for total runs scored is 7.5. 

The game is the marquee matchup of eight games on Thursday's MLB schedule. Other matchups include the Indians hosting the Yankees, the AL East-leading Red Sox taking on the Mariners, and the Mets visiting Chicago to meet the Cubs. Before making any MLB picks on those games or others during the evening, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a profitable start in 2021, going 21-14 on top-rated MLB money-line picks through three weeks, returning almost $300. 

Now, the model has crunched the numbers for the Thursday MLB schedule and posted its best bets for the evening games. Parlaying these four MLB picks would pay almost 12-1. Head to SportsLine to see the picks

Top MLB picks for Thursday, April 22

On Thursday, the model is high on the Red Sox-Mariners game to go over 9.5 runs (+100). That should be no surprise as Boston's lineup has been on fire to start the season. Since starting the year 0-3, the Red Sox have averaged 6.1 runs per game and gone 12-4. They lead the majors in several statistical categories, including runs scored (103), OPS (.815), slugging percentage (.470) and batting average (.285).

In addition Red Sox DH J.D. Martinez is having a bounce-back season. After a head-scratching 2020 (he hit a career-worst .213), Martinez is hitting .368 and has an OPS of 1.177. The model says the game goes over 9.5 runs in 60 percent of simulations.

Featured Game | Boston Red Sox vs. Seattle Mariners

How to make MLB predictions, parlays for Thursday, April 22

The model has locked in three other MLB best bets, including a strong play on Dodgers vs. Padres. It is also backing an underdog that helps push this parlay to a huge return. You can see the best bets only at SportsLine.

So which MLB picks should you make on Thursday for a shot at a big return of almost 12-1? And which underdog do you need to be all over? Visit SportsLine now to see Thursday's MLB picks, all from the projection model off to a fast start in 2021, and find out.