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The San Francisco Giants and Houston Astros, two of the best teams in baseball get set for a three-game interleague series when they meet Friday in San Francisco. The game from Oracle Park in San Francisco is set for 9:45 p.m. ET. The Giants (64-38) have the best record in baseball and lead the National League West Division, three games ahead of the defending World Series champion Los Angeles Dodgers. The Astros (63-40) are tied with Boston for the second-best mark in MLB. Houston leads the AL West, six games ahead of the Oakland Athletics.

The latest MLB odds for Friday from William Hill Sportsbook list the Giants at -125 (risk $125 to win $100) against the Astros. Other MLB lines of note include the New York Yankees (-160) against the Miami Marlins, the Detroit Tigers (-153) vs. the Baltimore Orioles and the Chicago White Sox as money-line favorites (-210) versus the Cleveland Indians. Before making any MLB picks or predictions on those games or others in the evening, you need to see what the SportsLine Projection Model has to say.

This model, which simulates every pitch of every game 10,000 times, is a profitable 132-109 on top-rated MLB money-line picks through 17 weeks in the 2021 season. It also had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. Anyone following it has seen some huge returns.

Now, the model has crunched the numbers for the MLB schedule today and posted its best bets. Parlaying these four MLB picks today will pay over 16-1. Head to SportsLine now to see the model's MLB picks.

Top MLB picks for Friday

The model likes the Chicago White Sox (-210 on the money line) to defeat the Cleveland Indians. The White Sox look to expand on their eight-game lead over the Indians in the AL Central. Chicago has the best home mark in the American League at 35-17 but has gone just 3-4 at Guaranteed Rate Field in Chicago this season. Shortstop Tim Anderson has had lots of success against Cleveland this season, with two home runs and six RBIs in seven games.

The Indians, meanwhile, have an opportunity to make inroads in the division and have won two of three. Right fielder Harold Ramirez has been a steadying force on offense for the Indians and is hitting .263 on the season with six homers, 25 RBIs and 25 runs scored in 67 games. In three games against the White Sox in 2021, he is batting .273 with a pair of RBIs. In six career games against them, Ramirez is a .250 hitter with a homer and three RBIs.

Featured Game | Chicago White Sox vs. Cleveland Indians

How to make MLB predictions, parlays

The model has locked in three other MLB best bets, including a number of underdogs. You can see its MLB picks today only at SportsLine.

So which MLB picks should you make on Friday for a more than 16-1 return? And which home team is a must-fade? Visit SportsLine now to see Friday's MLB picks, all from the projection model that's off to a sizzling start in 2021, and find out.