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The Los Angeles Dodgers are the defending world champions and the San Diego Padres entered the 2021 MLB season as a major contender after making several big offseason additions. But through the first two months of the campaign, the surprising San Francisco Giants find themselves atop the National League West Division standings. San Francisco looks to maintain that position and extend its winning streak to five games when it hosts the Los Angeles Angels for the finale of their two-game series on Tuesday. Should you expect the Giants to continue their winning ways, or is there value in the Angels to hand them a rare home loss and bring a return on the money line?

The latest MLB odds for Tuesday from William Hill Sportsbook list the Giants at -153 (risk $153 to win $100) against the Angels. Other MLB lines of note include the Milwaukee Brewers at -160 against the Detroit Tigers and the Chicago Cubs listed as slight money-line favorites (-111) versus the Padres. Before you lock in your MLB picks on those games or any others Tuesday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 71-52 on top-rated MLB money-line picks through nine weeks, returning over $800. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Tuesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay 18-1. Head to SportsLine to see the picks

Top MLB picks for Tuesday, June 1

The model likes the Seattle Mariners at +143 on the money line against the Oakland Athletics. Seattle is in the thick of things in the American League West as it trails first-place Oakland by 2 1/2 games after winning five straight and seven of its last eight. The Mariners extended their winning streak by defeating the Athletics 6-5 in 10 innings on Monday. Seattle squandered a 4-1 lead and fell behind in the top of the 10th before Ty France delivered an RBI single and scored on Tom Murphy's sacrifice fly in the bottom half.

The Mariners are hoping for a solid performance from Marco Gonzales (1-3, 5.40 ERA), who will be making his first start since April 27 due to a strained forearm. The 29-year-old left-hander had been pitching well prior to the injury, allowing fewer than three runs in three straight outings while yielding 10 hits over 18 innings in that span. Gonzales served up a total of one home run in those turns after surrendering five over his first two starts of the year.

How to make MLB predictions, parlays for Tuesday, June 1

The model has locked in three other MLB best bets, including one on a surprising underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Tuesday for a shot at a big return of 18-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Tuesday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.