The teams with the best records in Major League Baseball conclude their three-game series on Wednesday afternoon when the Chicago White Sox host the Tampa Bay Rays at Guaranteed Rate Field in Chicago. The Rays (43-25), who have the best record in the majors, won Game 1 of the series, 5-2, on Monday. The White Sox (42-25), who are tied with the Giants for the second best record, took Game 2 on Tuesday, 3-0. The White Sox are currently +650, while the Rays are +1400 to win the 2021 MLB championship in the latest 2021 MLB World Series odds at William Hill Sportsbook. 

First pitch on Wednesday is 2:10 p.m. ET. The White Sox are -127 money-line favorites in the latest White Sox vs. Rays odds from William Hill, while the Rays are +109 underdogs. The game is one of 15 on Wednesday's MLB schedule. Other matchups include the Blue Jays hosting the Yankees and the Cubs visiting Queens to meet the Mets. Before making any MLB picks or predictions on those games or others, you need to see the latest MLB predictions from the SportsLine Projection Model

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated MLB picks. It's off to a sizzling start in 2021, going 89-65 on top-rated MLB money-line picks through 11 weeks, returning well over $1,200. Anyone following it has seen huge rewards.

Now, the model has crunched the numbers for Wednesday's MLB schedule and posted its best bets. Parlaying these four MLB picks will pay more than 8-1. Head to SportsLine now to see the picks

Top MLB picks for Wednesday, June 16

One of the picks is the Dodgers (-145) to beat the Phillies at 10:10 p.m. ET. Los Angeles (41-26) has won three straight and occupy second in the loaded NL West. The Phillies (32-33) have dropped two-straight and sit in second place in the NL East, five games behind the division-leading Mets.

On Wednesday, Clayton Kershaw (8-5, 3.39 ERA) takes the mound for the Dodgers, and he's had success recently against Philadelphia. Los Angeles is 7-2 in the last nine games that he has started against the Phillies. Kershaw is 4-1 with a 1.45 ERA and 0.85 WHIP in those starts.

Featured Game | Los Angeles Dodgers vs. Philadelphia Phillies

How to make MLB predictions, parlays for Wednesday, June 16

The model has locked in three other MLB best bets, including a play on an American League underdog winning 65 percent of simulations. You can see these best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at a return of more than 8-1? And which underdog do you need to be all over? Visit SportsLine now to see Wednesday's top MLB picks, all from the projection model that is off to a fast start in 2021, and find out.