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The Houston Astros look to extend their winning streak to 12 games when they take on former manager A.J. Hinch and the Detroit Tigers on Friday at Comerica Park in Detroit. The streaking Astros (47-28) own the best record in the American League and have a two-game lead in the AL West over the A's. Meanwhile, the Tigers (32-43) sit in fourth place in the AL Central. First pitch is at 7:10 p.m. ET. 

The Astros are -260 money-line favorites in the latest Astros vs. Tigers odds from William Hill Sportsbook, while the Tigers are +230 underdogs. The game is one of 16 on Friday's MLB schedule. Other matchups include the rival Giants and A's meeting at Oracle Park in San Francisco and the Phillies and Mets playing a doubleheader at Citi Field. Before making any Tigers vs. Astros or any MLB picks, you need to see the latest predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It's off to a sizzling start in 2021, going 100-74 on top-rated MLB money-line picks through 12 weeks, returning more than $1,200. Anyone following it has seen huge returns.

Now, the model has crunched the numbers for Friday's MLB schedule and posted its best bets. Parlaying these four MLB picks will pay more than 10-1. Head to SportsLine to see the picks.

Top MLB picks for Friday, June 25

The model simulated every game on Friday's schedule 10,000 times and landed on Cleveland (+115) beating Minnesota at 8:10 p.m. ET. The Indians (41-31) have won seven of their last 10 games and beat the Twins 4-1 on Thursday night. Meanwhile, after putting together a season-best five-game winning streak, Minnesota (31-43) has now dropped two straight games and sits in last place in the five-team AL Central.

On Friday Cleveland arguably has the pitching edge. Indians starter Cal Quantrill has allowed only one run on seven hits and three walks while striking out eight over his last 11 innings. Meanwhile, after Friday's originally scheduled starter Randy Dobnak was forced to the IL, the Twins will be forced to piece together nine innings through their bullpen, which has a 4.82 ERA, seventh-worst in the majors.

Featured Game | Minnesota Twins vs. Cleveland Guardians

How to make MLB predictions, parlays

The model has locked in three other MLB best bets, including a play on an American League underdog. You can see its MLB best bets for June 25 only at SportsLine.

So which MLB picks should you make on Friday for a shot at a return of 10-1? And which American League underdog do you need to be all over? Visit SportsLine now to see Friday's MLB picks, all from the projection model that is off to a fast start in 2021, and find out.