After failing to record a victory over his first four starts of the 2021 MLB season, Jose Urquidy has been on a roll. The 26-year-old Houston Astros right-hander has won each of his last three turns, allowing just four runs and 13 hits over 20 innings. Urquidy hopes for another strong outing when he leads the Astros against the visiting Los Angeles Angels on Wednesday in the finale of their three-game series. Should you expect Urquidy to come up with his fourth straight excellent performance, or is there value in the Angels ending the streak and bringing a return on the money line? 

The latest MLB odds for Wednesday from WIlliam Hill Sportsbook list the Astros at -130 (risk $130 to win $100) against the Angels. Other MLB lines of note include the Los Angeles Dodgers at -250 against the Seattle Mariners and the Atlanta Braves listed as slight money-line favorites (-115) versus the Toronto Blue Jays. Before making any MLB picks or predictions on those games or others, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 44-31 on top-rated MLB money-line picks through six weeks, returning more than $700. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Wednesday and posted its best bets for the evening games. Parlaying these four MLB picks would pay 14-1. Head to SportsLine to see the picks

Top MLB picks for Wednesday, May 12

One of the MLB picks the model loves for Wednesday: the model is high on the Chicago White Sox (-140) to beat the Minnesota Twins. Chicago has been tearing it up offensively of late, scoring nine runs in four of its last six contests - including each of the last three during its four-game winning streak. The White Sox reached double digits in hits in every one of those nine-run efforts, with seven of the nine starters in their lineup notching at least one in Tuesday's 9-3 triumph over Minnesota. Dallas Keuchel certainly would appreciate a similar output from Chicago's offense when he takes the ball on Wednesday. 

Keuchel has come up with a scoreless performance in two of his last three starts but settled for a pair of no-decisions due to a lack of support. The former American League Cy Young Award winner scattered seven hits over six innings against Texas on Apr. 24 and held Cincinnati to two hits in seven frames last Wednesday, but the White Sox scored a total of one run while he was on the mound. The 33-year-old Keuchel is just 4-3 lifetime against the Twins but has posted a 3.12 ERA and recorded 38 strikeouts over 40 1/3 innings in eight games (seven starts).

Featured Game | Chicago White Sox vs. Minnesota Twins

How to make MLB predictions, parlays for Wednesday, May 12

The model has locked in three other MLB best bets, including one on a surprising underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Wednesday for a shot at a big return of 14-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Wednesday's MLB picks, all from the projection model off to a fast start in 2021, and find out.