It should be familiar for starter Yu Darvish on Monday night when his San Diego Padres host the Colorado Rockies as part of a slightly smaller early-week slate. Darvish faced the Rockies in his last start, pitching just four innings but holding Colorado to one unearned run off two hits. He was pulled for a pinch-hitter in the fifth, in the first game of a seven-inning doubleheader. He is now back in Petco Park and faces a Rockies team that is 2-14 and averages just 3.3 runs per game on the road. San Diego is a -210 favorite (risk $210 to win $100), while the Rockies are at +190 in the latest Rockies vs. Padres odds at William Hill Sportsbook. First pitch is set for 10:10 p.m. ET. 

That is one of the marquee matchups among the nine games on Monday's MLB schedule. Other games include Yankees ace Gerrit Cole facing the Rangers and the Mets and Braves, two NL East rivals, facing off in Atlanta. Before you lock in your MLB picks on those games or any others Monday night, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 52-36 on top-rated MLB money-line picks through seven weeks, returning over $900. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Monday and posted its best bets for the evening games. Parlaying these four MLB picks would pay 13-1. Head to SportsLine to see the picks

Top MLB picks for Monday, May 17

The model likes the high-scoring White Sox (-105) to get past the Minnesota Twins at Target Field. It's the same pitching matchup from last week's 13-8 White Sox victory, the second game of a three-game Chicago sweep. Twins left-hander J.A. Happ was roughed up for nine runs in 3.1 innings, and Dallas Keuchel got the win despite allowing six runs. The Twins are 7-13 in Minneapolis and are being outscored by their opponents by a half-run per game.

Meanwhile, the White Sox are plus-1.6 in run differential this season, the best mark in the majors, and they outscored Minnesota 26-13 in the three games last week. They are 10-7 on the road this year and have lost just twice to left-handed starters since the start of last season. Chicago is on a 16-6 run and is scoring more than five runs a game, with 34-year-old rookie Yermin Mercedes leading MLB with a .358 average and Jose Abreu tied for third with 33 RBIs. 

How to make MLB predictions, parlays for Monday, May 17

The model has locked in three other MLB best bets, including one on a big underdog. You can see the best bets only at SportsLine.

So which MLB picks should you make on Monday for a shot at a big return of 13-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Monday's top MLB picks, all from the projection model off to a fast start in 2021, and find out.